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Lysosome: regulator of lipid degradation pathways
Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal–autophagic pathway plays an impor...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Publishers
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/ https://www.ncbi.nlm.nih.gov/pubmed/25061009 http://dx.doi.org/10.1016/j.tcb.2014.06.006 |
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author | Settembre, Carmine Ballabio, Andrea |
author_facet | Settembre, Carmine Ballabio, Andrea |
author_sort | Settembre, Carmine |
collection | PubMed |
description | Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal–autophagic pathway plays an important part in the early steps of lipid degradation. In this review, we discuss the transcriptional mechanisms underlying co-regulation between lysosome, autophagy, and other steps of lipid catabolism, including the activity of nutrient-sensitive transcription factors (TFs) and of members of the nuclear receptor family. In addition, we discuss how the lysosome acts as a metabolic sensor and orchestrates the transcriptional response to fasting. |
format | Online Article Text |
id | pubmed-4247383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-42473832014-12-03 Lysosome: regulator of lipid degradation pathways Settembre, Carmine Ballabio, Andrea Trends Cell Biol Review Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal–autophagic pathway plays an important part in the early steps of lipid degradation. In this review, we discuss the transcriptional mechanisms underlying co-regulation between lysosome, autophagy, and other steps of lipid catabolism, including the activity of nutrient-sensitive transcription factors (TFs) and of members of the nuclear receptor family. In addition, we discuss how the lysosome acts as a metabolic sensor and orchestrates the transcriptional response to fasting. Elsevier Science Publishers 2014-12 /pmc/articles/PMC4247383/ /pubmed/25061009 http://dx.doi.org/10.1016/j.tcb.2014.06.006 Text en © 2014 The Authors https://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Review Settembre, Carmine Ballabio, Andrea Lysosome: regulator of lipid degradation pathways |
title | Lysosome: regulator of lipid degradation pathways |
title_full | Lysosome: regulator of lipid degradation pathways |
title_fullStr | Lysosome: regulator of lipid degradation pathways |
title_full_unstemmed | Lysosome: regulator of lipid degradation pathways |
title_short | Lysosome: regulator of lipid degradation pathways |
title_sort | lysosome: regulator of lipid degradation pathways |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/ https://www.ncbi.nlm.nih.gov/pubmed/25061009 http://dx.doi.org/10.1016/j.tcb.2014.06.006 |
work_keys_str_mv | AT settembrecarmine lysosomeregulatoroflipiddegradationpathways AT ballabioandrea lysosomeregulatoroflipiddegradationpathways |