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Eryptosis as a marker of Parkinson's disease

A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of...

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Autores principales: Pretorius, Etheresia, Swanepoel, Albe C, Buys, Antoinette V, Vermeulen, Natasha, Duim, Wiebren, Kell, Douglas B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247384/
https://www.ncbi.nlm.nih.gov/pubmed/25411230
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author Pretorius, Etheresia
Swanepoel, Albe C
Buys, Antoinette V
Vermeulen, Natasha
Duim, Wiebren
Kell, Douglas B
author_facet Pretorius, Etheresia
Swanepoel, Albe C
Buys, Antoinette V
Vermeulen, Natasha
Duim, Wiebren
Kell, Douglas B
author_sort Pretorius, Etheresia
collection PubMed
description A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases. In the current work, we focus on inflammatory signalling in PD, using a systems approach that allows us to look at the disease in a more holistic way. We discuss cyclooxygenases, prostaglandins, thromboxanes and also iron in PD. These particular signalling molecules are involved in PD pathophysiology, but are also very important in an aberrant coagulation/hematology system. We present and discuss a hypothesis regarding the possible interaction of these aberrant signalling molecules implicated in PD, and suggest that these molecules may affect the erythrocytes of PD patients. This would be observable as changes in the morphology of the RBCs and of PD patients relative to healthy controls. We then show that the RBCs of PD patients are indeed rather dramatically deranged in their morphology, exhibiting eryptosis (a kind of programmed cell death). This morphological indicator may have useful diagnostic and prognostic significance.
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spelling pubmed-42473842014-12-08 Eryptosis as a marker of Parkinson's disease Pretorius, Etheresia Swanepoel, Albe C Buys, Antoinette V Vermeulen, Natasha Duim, Wiebren Kell, Douglas B Aging (Albany NY) Research Paper A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases. In the current work, we focus on inflammatory signalling in PD, using a systems approach that allows us to look at the disease in a more holistic way. We discuss cyclooxygenases, prostaglandins, thromboxanes and also iron in PD. These particular signalling molecules are involved in PD pathophysiology, but are also very important in an aberrant coagulation/hematology system. We present and discuss a hypothesis regarding the possible interaction of these aberrant signalling molecules implicated in PD, and suggest that these molecules may affect the erythrocytes of PD patients. This would be observable as changes in the morphology of the RBCs and of PD patients relative to healthy controls. We then show that the RBCs of PD patients are indeed rather dramatically deranged in their morphology, exhibiting eryptosis (a kind of programmed cell death). This morphological indicator may have useful diagnostic and prognostic significance. Impact Journals LLC 2014-10-30 /pmc/articles/PMC4247384/ /pubmed/25411230 Text en Copyright: © 2014 Pretorius et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Paper
Pretorius, Etheresia
Swanepoel, Albe C
Buys, Antoinette V
Vermeulen, Natasha
Duim, Wiebren
Kell, Douglas B
Eryptosis as a marker of Parkinson's disease
title Eryptosis as a marker of Parkinson's disease
title_full Eryptosis as a marker of Parkinson's disease
title_fullStr Eryptosis as a marker of Parkinson's disease
title_full_unstemmed Eryptosis as a marker of Parkinson's disease
title_short Eryptosis as a marker of Parkinson's disease
title_sort eryptosis as a marker of parkinson's disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247384/
https://www.ncbi.nlm.nih.gov/pubmed/25411230
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