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Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C

Background: Different factors like age, sex, route of infection, initial viral load, levels of liver function tests and genotypes may affect response to treatment in patients with chronic hepatitis C. The purpose of this study was to determine the role of these factors in the treatment of these pati...

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Autores principales: Heidari, Mehdi, Bayani, Masomeh, Bijani, Ali, Hasanjani Roushan, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247485/
https://www.ncbi.nlm.nih.gov/pubmed/25489433
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author Heidari, Mehdi
Bayani, Masomeh
Bijani, Ali
Hasanjani Roushan, Mohammad Reza
author_facet Heidari, Mehdi
Bayani, Masomeh
Bijani, Ali
Hasanjani Roushan, Mohammad Reza
author_sort Heidari, Mehdi
collection PubMed
description Background: Different factors like age, sex, route of infection, initial viral load, levels of liver function tests and genotypes may affect response to treatment in patients with chronic hepatitis C. The purpose of this study was to determine the role of these factors in the treatment of these patients. Methods: From 2004 to 2012, different genotypes of chronic HCV (Hepatitis C virus) patients in Babol, North of Iran who were treated with pegylated interferon plus ribavirin with standard doses (48 weeks for genotype 1, and 24 weeks for genotypes 2 and 3) were entered in the study. HCV RNA was measured during and after treatment based on genotype and protocol. The outcome measure was defined as sustained virological response (SVR) (negative HCV RNA after six months of therapy) was achieved. The data were collected and analyzed. Results: The mean age of the patients (61 males, 5 females) was 33.82±9.64 years. Twenty seven (40.9%), 37 (56.1%) and 2 (%3) were genotypes 1, 2 and 3, respectively. Twenty one (77.8%) with genotype 1, and 34 (91.9%) with genotype 3 achieved SVR (P=0.045). Fifty-five of 61 men (90.2%) and 2 out of 5 females (40%) achieved SVR (P=0.01). SVR was seen in 22 (88%) of 25 IV drug patients versus in 35 (85.4%) of the non-addict cases (p>0.05). There were no significant differences regarding age, viral load, and liver aminotransferase levels with treatment. Conclusion: The results show that genotypes 2 and 3, and the male sex had better SVR. Further studies with large number of cases are recommended.
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spelling pubmed-42474852014-12-08 Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C Heidari, Mehdi Bayani, Masomeh Bijani, Ali Hasanjani Roushan, Mohammad Reza Caspian J Intern Med Short Communication Background: Different factors like age, sex, route of infection, initial viral load, levels of liver function tests and genotypes may affect response to treatment in patients with chronic hepatitis C. The purpose of this study was to determine the role of these factors in the treatment of these patients. Methods: From 2004 to 2012, different genotypes of chronic HCV (Hepatitis C virus) patients in Babol, North of Iran who were treated with pegylated interferon plus ribavirin with standard doses (48 weeks for genotype 1, and 24 weeks for genotypes 2 and 3) were entered in the study. HCV RNA was measured during and after treatment based on genotype and protocol. The outcome measure was defined as sustained virological response (SVR) (negative HCV RNA after six months of therapy) was achieved. The data were collected and analyzed. Results: The mean age of the patients (61 males, 5 females) was 33.82±9.64 years. Twenty seven (40.9%), 37 (56.1%) and 2 (%3) were genotypes 1, 2 and 3, respectively. Twenty one (77.8%) with genotype 1, and 34 (91.9%) with genotype 3 achieved SVR (P=0.045). Fifty-five of 61 men (90.2%) and 2 out of 5 females (40%) achieved SVR (P=0.01). SVR was seen in 22 (88%) of 25 IV drug patients versus in 35 (85.4%) of the non-addict cases (p>0.05). There were no significant differences regarding age, viral load, and liver aminotransferase levels with treatment. Conclusion: The results show that genotypes 2 and 3, and the male sex had better SVR. Further studies with large number of cases are recommended. Babol University of Medical Sciences 2014 /pmc/articles/PMC4247485/ /pubmed/25489433 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Heidari, Mehdi
Bayani, Masomeh
Bijani, Ali
Hasanjani Roushan, Mohammad Reza
Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title_full Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title_fullStr Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title_full_unstemmed Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title_short Factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis C
title_sort factors influencing therapeutic response to pegylated interferon plus ribavirin in the different genotypes of chronic hepatitis c
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247485/
https://www.ncbi.nlm.nih.gov/pubmed/25489433
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