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Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)

The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in v...

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Autores principales: Zeljenková, Dagmar, Ambrušová, Katarína, Bartušová, Mária, Kebis, Anton, Kovrižnych, Jevgenij, Krivošíková, Zora, Kuricová, Miroslava, Líšková, Aurélia, Rollerová, Eva, Spustová, Viera, Szabová, Elena, Tulinská, Jana, Wimmerová, Soňa, Levkut, Mikuláš, Révajová, Viera, Ševčíková, Zuzana, Schmidt, Kerstin, Schmidtke, Jörg, La Paz, Jose Luis, Corujo, Maria, Pla, Maria, Kleter, Gijs A., Kok, Esther J., Sharbati, Jutta, Hanisch, Carlos, Einspanier, Ralf, Adel-Patient, Karine, Wal, Jean-Michel, Spök, Armin, Pöting, Annette, Kohl, Christian, Wilhelm, Ralf, Schiemann, Joachim, Steinberg, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247492/
https://www.ncbi.nlm.nih.gov/pubmed/25270621
http://dx.doi.org/10.1007/s00204-014-1374-8
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author Zeljenková, Dagmar
Ambrušová, Katarína
Bartušová, Mária
Kebis, Anton
Kovrižnych, Jevgenij
Krivošíková, Zora
Kuricová, Miroslava
Líšková, Aurélia
Rollerová, Eva
Spustová, Viera
Szabová, Elena
Tulinská, Jana
Wimmerová, Soňa
Levkut, Mikuláš
Révajová, Viera
Ševčíková, Zuzana
Schmidt, Kerstin
Schmidtke, Jörg
La Paz, Jose Luis
Corujo, Maria
Pla, Maria
Kleter, Gijs A.
Kok, Esther J.
Sharbati, Jutta
Hanisch, Carlos
Einspanier, Ralf
Adel-Patient, Karine
Wal, Jean-Michel
Spök, Armin
Pöting, Annette
Kohl, Christian
Wilhelm, Ralf
Schiemann, Joachim
Steinberg, Pablo
author_facet Zeljenková, Dagmar
Ambrušová, Katarína
Bartušová, Mária
Kebis, Anton
Kovrižnych, Jevgenij
Krivošíková, Zora
Kuricová, Miroslava
Líšková, Aurélia
Rollerová, Eva
Spustová, Viera
Szabová, Elena
Tulinská, Jana
Wimmerová, Soňa
Levkut, Mikuláš
Révajová, Viera
Ševčíková, Zuzana
Schmidt, Kerstin
Schmidtke, Jörg
La Paz, Jose Luis
Corujo, Maria
Pla, Maria
Kleter, Gijs A.
Kok, Esther J.
Sharbati, Jutta
Hanisch, Carlos
Einspanier, Ralf
Adel-Patient, Karine
Wal, Jean-Michel
Spök, Armin
Pöting, Annette
Kohl, Christian
Wilhelm, Ralf
Schiemann, Joachim
Steinberg, Pablo
author_sort Zeljenková, Dagmar
collection PubMed
description The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00204-014-1374-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-42474922014-12-03 Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE) Zeljenková, Dagmar Ambrušová, Katarína Bartušová, Mária Kebis, Anton Kovrižnych, Jevgenij Krivošíková, Zora Kuricová, Miroslava Líšková, Aurélia Rollerová, Eva Spustová, Viera Szabová, Elena Tulinská, Jana Wimmerová, Soňa Levkut, Mikuláš Révajová, Viera Ševčíková, Zuzana Schmidt, Kerstin Schmidtke, Jörg La Paz, Jose Luis Corujo, Maria Pla, Maria Kleter, Gijs A. Kok, Esther J. Sharbati, Jutta Hanisch, Carlos Einspanier, Ralf Adel-Patient, Karine Wal, Jean-Michel Spök, Armin Pöting, Annette Kohl, Christian Wilhelm, Ralf Schiemann, Joachim Steinberg, Pablo Arch Toxicol Biologics The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00204-014-1374-8) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-10-02 2014 /pmc/articles/PMC4247492/ /pubmed/25270621 http://dx.doi.org/10.1007/s00204-014-1374-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Biologics
Zeljenková, Dagmar
Ambrušová, Katarína
Bartušová, Mária
Kebis, Anton
Kovrižnych, Jevgenij
Krivošíková, Zora
Kuricová, Miroslava
Líšková, Aurélia
Rollerová, Eva
Spustová, Viera
Szabová, Elena
Tulinská, Jana
Wimmerová, Soňa
Levkut, Mikuláš
Révajová, Viera
Ševčíková, Zuzana
Schmidt, Kerstin
Schmidtke, Jörg
La Paz, Jose Luis
Corujo, Maria
Pla, Maria
Kleter, Gijs A.
Kok, Esther J.
Sharbati, Jutta
Hanisch, Carlos
Einspanier, Ralf
Adel-Patient, Karine
Wal, Jean-Michel
Spök, Armin
Pöting, Annette
Kohl, Christian
Wilhelm, Ralf
Schiemann, Joachim
Steinberg, Pablo
Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title_full Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title_fullStr Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title_full_unstemmed Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title_short Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
title_sort ninety-day oral toxicity studies on two genetically modified maize mon810 varieties in wistar han rcc rats (eu 7th framework programme project grace)
topic Biologics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247492/
https://www.ncbi.nlm.nih.gov/pubmed/25270621
http://dx.doi.org/10.1007/s00204-014-1374-8
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