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Sex hormones in gender-specific risk for head and neck cancer: A review

Despite the fact that numerous researches have been carried out to prevent head and neck cancer (HNC) and treat those patients, there is no reduction in morbidity rate because the underlying molecular pathogenesis is still poorly understood. Endocrine microenvironment is another vital factor besides...

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Autores principales: Nainani, Purshotam, Paliwal, Aparna, Nagpal, Neelu, Agrawal, Mayank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247543/
https://www.ncbi.nlm.nih.gov/pubmed/25452920
http://dx.doi.org/10.4103/2231-0762.144557
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author Nainani, Purshotam
Paliwal, Aparna
Nagpal, Neelu
Agrawal, Mayank
author_facet Nainani, Purshotam
Paliwal, Aparna
Nagpal, Neelu
Agrawal, Mayank
author_sort Nainani, Purshotam
collection PubMed
description Despite the fact that numerous researches have been carried out to prevent head and neck cancer (HNC) and treat those patients, there is no reduction in morbidity rate because the underlying molecular pathogenesis is still poorly understood. Endocrine microenvironment is another vital factor besides other traditional risk factors like tobacco smoking, infections, and alcohol. It has been proven that sex hormone receptors are also expressed in larynx and lungs, in addition to sex organs. Sex hormones play a vital role in gene expression involved in the plethora of biological and neoplastic processes. The role of sex hormones in HNC is still divisive and very few researches have been conducted to describe their role. So, this article is an effort to attract the attention of researchers, endocrinologists, pathologists, and clinicians toward the impending role of sex hormones, with special emphasis on progesterone, estrogen, and prolactin in HNC onset and progression, along with their therapeutic role.
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spelling pubmed-42475432014-12-01 Sex hormones in gender-specific risk for head and neck cancer: A review Nainani, Purshotam Paliwal, Aparna Nagpal, Neelu Agrawal, Mayank J Int Soc Prev Community Dent Review Article Despite the fact that numerous researches have been carried out to prevent head and neck cancer (HNC) and treat those patients, there is no reduction in morbidity rate because the underlying molecular pathogenesis is still poorly understood. Endocrine microenvironment is another vital factor besides other traditional risk factors like tobacco smoking, infections, and alcohol. It has been proven that sex hormone receptors are also expressed in larynx and lungs, in addition to sex organs. Sex hormones play a vital role in gene expression involved in the plethora of biological and neoplastic processes. The role of sex hormones in HNC is still divisive and very few researches have been conducted to describe their role. So, this article is an effort to attract the attention of researchers, endocrinologists, pathologists, and clinicians toward the impending role of sex hormones, with special emphasis on progesterone, estrogen, and prolactin in HNC onset and progression, along with their therapeutic role. Medknow Publications & Media Pvt Ltd 2014-11 /pmc/articles/PMC4247543/ /pubmed/25452920 http://dx.doi.org/10.4103/2231-0762.144557 Text en Copyright: © Journal of International Society of Preventive and Community Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nainani, Purshotam
Paliwal, Aparna
Nagpal, Neelu
Agrawal, Mayank
Sex hormones in gender-specific risk for head and neck cancer: A review
title Sex hormones in gender-specific risk for head and neck cancer: A review
title_full Sex hormones in gender-specific risk for head and neck cancer: A review
title_fullStr Sex hormones in gender-specific risk for head and neck cancer: A review
title_full_unstemmed Sex hormones in gender-specific risk for head and neck cancer: A review
title_short Sex hormones in gender-specific risk for head and neck cancer: A review
title_sort sex hormones in gender-specific risk for head and neck cancer: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247543/
https://www.ncbi.nlm.nih.gov/pubmed/25452920
http://dx.doi.org/10.4103/2231-0762.144557
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