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Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan

BACKGROUND: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have high...

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Autores principales: Klahan, Sukhontip, Kuo, Chun-Nan, Chien, Shu-Chen, Lin, Yea-Wen, Lin, Chun-Yi, Lin, Chia-Hsien, Chang, Wei-Chiao, Lin, Ching-I, Hung, Kuo-Sheng, Chang, Wei-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247648/
https://www.ncbi.nlm.nih.gov/pubmed/25404001
http://dx.doi.org/10.1186/s12876-014-0192-z
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author Klahan, Sukhontip
Kuo, Chun-Nan
Chien, Shu-Chen
Lin, Yea-Wen
Lin, Chun-Yi
Lin, Chia-Hsien
Chang, Wei-Chiao
Lin, Ching-I
Hung, Kuo-Sheng
Chang, Wei-Pin
author_facet Klahan, Sukhontip
Kuo, Chun-Nan
Chien, Shu-Chen
Lin, Yea-Wen
Lin, Chun-Yi
Lin, Chia-Hsien
Chang, Wei-Chiao
Lin, Ching-I
Hung, Kuo-Sheng
Chang, Wei-Pin
author_sort Klahan, Sukhontip
collection PubMed
description BACKGROUND: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. METHODS: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. RESULTS: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p < 0 .01). CONCLUSION: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.
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spelling pubmed-42476482014-11-30 Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan Klahan, Sukhontip Kuo, Chun-Nan Chien, Shu-Chen Lin, Yea-Wen Lin, Chun-Yi Lin, Chia-Hsien Chang, Wei-Chiao Lin, Ching-I Hung, Kuo-Sheng Chang, Wei-Pin BMC Gastroenterol Research Article BACKGROUND: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. METHODS: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. RESULTS: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p < 0 .01). CONCLUSION: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population. BioMed Central 2014-11-18 /pmc/articles/PMC4247648/ /pubmed/25404001 http://dx.doi.org/10.1186/s12876-014-0192-z Text en © Klahan et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Klahan, Sukhontip
Kuo, Chun-Nan
Chien, Shu-Chen
Lin, Yea-Wen
Lin, Chun-Yi
Lin, Chia-Hsien
Chang, Wei-Chiao
Lin, Ching-I
Hung, Kuo-Sheng
Chang, Wei-Pin
Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title_full Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title_fullStr Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title_full_unstemmed Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title_short Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan
title_sort osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247648/
https://www.ncbi.nlm.nih.gov/pubmed/25404001
http://dx.doi.org/10.1186/s12876-014-0192-z
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