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Vaccines, emerging viruses, and how to avoid disaster

Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine b...

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Autor principal: Rappuoli, Rino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247664/
https://www.ncbi.nlm.nih.gov/pubmed/25432510
http://dx.doi.org/10.1186/s12915-014-0100-6
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author_facet Rappuoli, Rino
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description Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic mutant of diphtheria toxin which has since become the basis for conjugate vaccines against haemophilus, meningococcus, and pneumococcal infections, before returning to the Sclavo Research Center where he developed an acellular vaccine based on a mutant pertussis toxin. With many achievements in vaccine development to his credit, he is now Global Head of Vaccines Research and Development for Novartis Vaccines in Siena, and has most recently pioneered reverse vaccinology, in which the genome of the pathogen is screened for candidate antigenic and immunogenic vaccine components. We spoke to him about the potential for outbreaks of the kind we are now seeing with Ebolavirus in West Africa, and what can be done to prevent them.
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spelling pubmed-42476642014-11-30 Vaccines, emerging viruses, and how to avoid disaster Rappuoli, Rino BMC Biol Interview Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic mutant of diphtheria toxin which has since become the basis for conjugate vaccines against haemophilus, meningococcus, and pneumococcal infections, before returning to the Sclavo Research Center where he developed an acellular vaccine based on a mutant pertussis toxin. With many achievements in vaccine development to his credit, he is now Global Head of Vaccines Research and Development for Novartis Vaccines in Siena, and has most recently pioneered reverse vaccinology, in which the genome of the pathogen is screened for candidate antigenic and immunogenic vaccine components. We spoke to him about the potential for outbreaks of the kind we are now seeing with Ebolavirus in West Africa, and what can be done to prevent them. BioMed Central 2014-11-29 /pmc/articles/PMC4247664/ /pubmed/25432510 http://dx.doi.org/10.1186/s12915-014-0100-6 Text en © Rappuoli; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Interview
Rappuoli, Rino
Vaccines, emerging viruses, and how to avoid disaster
title Vaccines, emerging viruses, and how to avoid disaster
title_full Vaccines, emerging viruses, and how to avoid disaster
title_fullStr Vaccines, emerging viruses, and how to avoid disaster
title_full_unstemmed Vaccines, emerging viruses, and how to avoid disaster
title_short Vaccines, emerging viruses, and how to avoid disaster
title_sort vaccines, emerging viruses, and how to avoid disaster
topic Interview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247664/
https://www.ncbi.nlm.nih.gov/pubmed/25432510
http://dx.doi.org/10.1186/s12915-014-0100-6
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