Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models

BACKGROUND: Tau is an axonal protein that binds to and regulates microtubule function. Hyper-phosphorylation of Tau reduces its binding to microtubules and it is associated with β-amyloid deposition in Alzheimer’s disease. Paradoxically, Tau reduction may prevent β-amyloid pathology, raising the pos...

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Detalles Bibliográficos
Autores principales: Lonskaya, Irina, Hebron, Michaeline, Chen, Wenqiang, Schachter, Joel, Moussa, Charbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247762/
https://www.ncbi.nlm.nih.gov/pubmed/25384392
http://dx.doi.org/10.1186/1750-1326-9-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247762/
https://www.ncbi.nlm.nih.gov/pubmed/25384392
http://dx.doi.org/10.1186/1750-1326-9-46

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