Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

BACKGROUND: Cisplatin, a platinum-derived chemotherapeutic agent, produces antineoplastic effects coupled with toxic neuropathic pain and impaired general health status. These side-effects complicate long term studies of neuropathy or analgesic interventions in animals. We recently demonstrated that...

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Detalles Bibliográficos
Autores principales: Guindon, Josée, Deng, Liting, Fan, Baochang, Wager-Miller, Jim, Hohmann, Andrea G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247770/
https://www.ncbi.nlm.nih.gov/pubmed/25189223
http://dx.doi.org/10.1186/1744-8069-10-56

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