The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms

Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this st...

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Detalles Bibliográficos
Autores principales: Jin, Shumei, Zhang, Mixia, Gao, Yan, Zhang, Xuebin, Cui, Guangzhi, Zhang, Yanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247915/
https://www.ncbi.nlm.nih.gov/pubmed/25538944
http://dx.doi.org/10.1155/2014/259412
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author Jin, Shumei
Zhang, Mixia
Gao, Yan
Zhang, Xuebin
Cui, Guangzhi
Zhang, Yanjun
author_facet Jin, Shumei
Zhang, Mixia
Gao, Yan
Zhang, Xuebin
Cui, Guangzhi
Zhang, Yanjun
author_sort Jin, Shumei
collection PubMed
description Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.
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spelling pubmed-42479152014-12-23 The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms Jin, Shumei Zhang, Mixia Gao, Yan Zhang, Xuebin Cui, Guangzhi Zhang, Yanjun J Diabetes Res Research Article Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA. Hindawi Publishing Corporation 2014 2014-11-16 /pmc/articles/PMC4247915/ /pubmed/25538944 http://dx.doi.org/10.1155/2014/259412 Text en Copyright © 2014 Shumei Jin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jin, Shumei
Zhang, Mixia
Gao, Yan
Zhang, Xuebin
Cui, Guangzhi
Zhang, Yanjun
The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title_full The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title_fullStr The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title_full_unstemmed The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title_short The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
title_sort efficacy of jing wan hong ointment for nerve injury diabetic foot ulcer and its mechanisms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247915/
https://www.ncbi.nlm.nih.gov/pubmed/25538944
http://dx.doi.org/10.1155/2014/259412
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