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Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract of Morus alba and Polygonum odoratum leaves. Ovariectomized rats, weighing 200–220 g, were oral...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247956/ https://www.ncbi.nlm.nih.gov/pubmed/25478061 http://dx.doi.org/10.1155/2014/579305 |
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author | Sungkamanee, Sudarat Wattanathorn, Jintanaporn Muchimapura, Supaporn Thukham-mee, Wipawee |
author_facet | Sungkamanee, Sudarat Wattanathorn, Jintanaporn Muchimapura, Supaporn Thukham-mee, Wipawee |
author_sort | Sungkamanee, Sudarat |
collection | PubMed |
description | Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract of Morus alba and Polygonum odoratum leaves. Ovariectomized rats, weighing 200–220 g, were orally given the combined extract at doses of 5, 150, and 300 mg·kg(−1) BW for 3 months. At the end of study, blood was collected to determine serum osteocalcin, calcium, and alkaline phosphatase level. In addition, tibia bone was isolated to determine bone oxidative stress markers, cortical bone thickness, and density of osteoblast. The combined extract decreased oxidative stress and osteoclast density but increased osteoblast density and cortical thickness. The elevation of serum calcium, alkaline phosphatase, and osteocalcin was also observed. These results suggested the antiosteoporotic effect of the combined extract via the increased growth formation together with the suppression of bone resorption. However, further studies concerning chronic toxicity and the underlying mechanism are required. |
format | Online Article Text |
id | pubmed-4247956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42479562014-12-04 Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum Sungkamanee, Sudarat Wattanathorn, Jintanaporn Muchimapura, Supaporn Thukham-mee, Wipawee Oxid Med Cell Longev Research Article Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract of Morus alba and Polygonum odoratum leaves. Ovariectomized rats, weighing 200–220 g, were orally given the combined extract at doses of 5, 150, and 300 mg·kg(−1) BW for 3 months. At the end of study, blood was collected to determine serum osteocalcin, calcium, and alkaline phosphatase level. In addition, tibia bone was isolated to determine bone oxidative stress markers, cortical bone thickness, and density of osteoblast. The combined extract decreased oxidative stress and osteoclast density but increased osteoblast density and cortical thickness. The elevation of serum calcium, alkaline phosphatase, and osteocalcin was also observed. These results suggested the antiosteoporotic effect of the combined extract via the increased growth formation together with the suppression of bone resorption. However, further studies concerning chronic toxicity and the underlying mechanism are required. Hindawi Publishing Corporation 2014 2014-11-12 /pmc/articles/PMC4247956/ /pubmed/25478061 http://dx.doi.org/10.1155/2014/579305 Text en Copyright © 2014 Sudarat Sungkamanee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sungkamanee, Sudarat Wattanathorn, Jintanaporn Muchimapura, Supaporn Thukham-mee, Wipawee Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum |
title | Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
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title_full | Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
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title_fullStr | Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
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title_full_unstemmed | Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
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title_short | Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
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title_sort | antiosteoporotic effect of combined extract of morus alba and polygonum odoratum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247956/ https://www.ncbi.nlm.nih.gov/pubmed/25478061 http://dx.doi.org/10.1155/2014/579305 |
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