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Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development
In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotei...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248294/ https://www.ncbi.nlm.nih.gov/pubmed/25452274 http://dx.doi.org/10.1101/gad.249763.114 |
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author | Rodenfels, Jonathan Lavrynenko, Oksana Ayciriex, Sophie Sampaio, Julio L. Carvalho, Maria Shevchenko, Andrej Eaton, Suzanne |
author_facet | Rodenfels, Jonathan Lavrynenko, Oksana Ayciriex, Sophie Sampaio, Julio L. Carvalho, Maria Shevchenko, Andrej Eaton, Suzanne |
author_sort | Rodenfels, Jonathan |
collection | PubMed |
description | In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth. It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability. |
format | Online Article Text |
id | pubmed-4248294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42482942015-06-01 Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development Rodenfels, Jonathan Lavrynenko, Oksana Ayciriex, Sophie Sampaio, Julio L. Carvalho, Maria Shevchenko, Andrej Eaton, Suzanne Genes Dev Research Paper In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth. It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability. Cold Spring Harbor Laboratory Press 2014-12-01 /pmc/articles/PMC4248294/ /pubmed/25452274 http://dx.doi.org/10.1101/gad.249763.114 Text en © 2014 Rodenfels et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Paper Rodenfels, Jonathan Lavrynenko, Oksana Ayciriex, Sophie Sampaio, Julio L. Carvalho, Maria Shevchenko, Andrej Eaton, Suzanne Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title | Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title_full | Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title_fullStr | Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title_full_unstemmed | Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title_short | Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |
title_sort | production of systemically circulating hedgehog by the intestine couples nutrition to growth and development |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248294/ https://www.ncbi.nlm.nih.gov/pubmed/25452274 http://dx.doi.org/10.1101/gad.249763.114 |
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