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Clinical & biochemical profile of trichinellosis outbreak in north India

BACKGROUND & OBJECTIVES: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis...

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Autores principales: Sharma, Rahul K., Raghavendra, N., Mohanty, Smita, Tripathi, Brijendra K., Gupta, B., Goel, Ankita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248389/
https://www.ncbi.nlm.nih.gov/pubmed/25366210
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author Sharma, Rahul K.
Raghavendra, N.
Mohanty, Smita
Tripathi, Brijendra K.
Gupta, B.
Goel, Ankita
author_facet Sharma, Rahul K.
Raghavendra, N.
Mohanty, Smita
Tripathi, Brijendra K.
Gupta, B.
Goel, Ankita
author_sort Sharma, Rahul K.
collection PubMed
description BACKGROUND & OBJECTIVES: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis outbreak in a village in Tehri Garhwal district of Uttarakhand state in north India. METHODS: Three index cases presenting as acute febrile myalgia syndrome with eosinophilia, after consumption of uncooked pork in a common feast, were confirmed as trichinellosis on muscle biopsy. A detailed epidemiological survey was carried out in the affected community and all the people who participated in the feast were investigated for clinical and biochemical profile. RESULTS: A total of 54 patients were evaluated in the study. The type of pork consumed included uncooked in 24 per cent (n=13), open fire roasted in 39 per cent (n=21) and fried in 37 per cent (n=20). Clinical symptoms were found in those who consumed pork in uncooked or open fire roasted form (n=34). These included fever with chills and myalgia (100%), periorbital oedema (67%), dyspnoea (9%), and dysphagia (3%). Laboratory parameters studied in both symptomatic and asymptomatic patients showed eosinophilia in 90 per cent (n=41), raised ESR in 98 per cent (n=45), and an elevated creatinine phosphokinase (CPK) level in 85 per cent (n=39). All symptomatic patients were treated with a short course of oral steroids and albendazole therapy. CONCLUSIONS: Trichinella infection is not uncommon in India, and should be suspected in case of acute febrile myalgia especially in areas, where habits of consumption of raw meat is more prevalent.
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spelling pubmed-42483892014-12-05 Clinical & biochemical profile of trichinellosis outbreak in north India Sharma, Rahul K. Raghavendra, N. Mohanty, Smita Tripathi, Brijendra K. Gupta, B. Goel, Ankita Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis outbreak in a village in Tehri Garhwal district of Uttarakhand state in north India. METHODS: Three index cases presenting as acute febrile myalgia syndrome with eosinophilia, after consumption of uncooked pork in a common feast, were confirmed as trichinellosis on muscle biopsy. A detailed epidemiological survey was carried out in the affected community and all the people who participated in the feast were investigated for clinical and biochemical profile. RESULTS: A total of 54 patients were evaluated in the study. The type of pork consumed included uncooked in 24 per cent (n=13), open fire roasted in 39 per cent (n=21) and fried in 37 per cent (n=20). Clinical symptoms were found in those who consumed pork in uncooked or open fire roasted form (n=34). These included fever with chills and myalgia (100%), periorbital oedema (67%), dyspnoea (9%), and dysphagia (3%). Laboratory parameters studied in both symptomatic and asymptomatic patients showed eosinophilia in 90 per cent (n=41), raised ESR in 98 per cent (n=45), and an elevated creatinine phosphokinase (CPK) level in 85 per cent (n=39). All symptomatic patients were treated with a short course of oral steroids and albendazole therapy. CONCLUSIONS: Trichinella infection is not uncommon in India, and should be suspected in case of acute febrile myalgia especially in areas, where habits of consumption of raw meat is more prevalent. Medknow Publications & Media Pvt Ltd 2014-09 /pmc/articles/PMC4248389/ /pubmed/25366210 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sharma, Rahul K.
Raghavendra, N.
Mohanty, Smita
Tripathi, Brijendra K.
Gupta, B.
Goel, Ankita
Clinical & biochemical profile of trichinellosis outbreak in north India
title Clinical & biochemical profile of trichinellosis outbreak in north India
title_full Clinical & biochemical profile of trichinellosis outbreak in north India
title_fullStr Clinical & biochemical profile of trichinellosis outbreak in north India
title_full_unstemmed Clinical & biochemical profile of trichinellosis outbreak in north India
title_short Clinical & biochemical profile of trichinellosis outbreak in north India
title_sort clinical & biochemical profile of trichinellosis outbreak in north india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248389/
https://www.ncbi.nlm.nih.gov/pubmed/25366210
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