Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

BACKGROUND: High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary hypertensi...

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Detalles Bibliográficos
Autores principales: Yang, Pil-Sung, Kim, Dae-Hoon, Lee, Yong Joon, Lee, Sang-Eun, Kang, Won Jun, Chang, Hyuk-Jae, Shin, Jeon-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248446/
https://www.ncbi.nlm.nih.gov/pubmed/25420924
http://dx.doi.org/10.1186/s12931-014-0148-4

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