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Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study
BACKGROUND: Early diagnosis and prompt effective therapy are crucial for the prevention of tuberculosis (TB) transmission, particularly in regions with high levels of multi-drug resistant TB. This study aimed to evaluate the extent of delay in diagnosis and treatment of TB in Uzbekistan and identify...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248454/ https://www.ncbi.nlm.nih.gov/pubmed/25421106 http://dx.doi.org/10.1186/s12879-014-0624-y |
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author | Belkina, Tatiana V Khojiev, Doniyor S Tillyashaykhov, Mirzagaleb N Tigay, Zinaida N Kudenov, Marat U Tebbens, Jurjen Duintjer Vlcek, Jiri |
author_facet | Belkina, Tatiana V Khojiev, Doniyor S Tillyashaykhov, Mirzagaleb N Tigay, Zinaida N Kudenov, Marat U Tebbens, Jurjen Duintjer Vlcek, Jiri |
author_sort | Belkina, Tatiana V |
collection | PubMed |
description | BACKGROUND: Early diagnosis and prompt effective therapy are crucial for the prevention of tuberculosis (TB) transmission, particularly in regions with high levels of multi-drug resistant TB. This study aimed to evaluate the extent of delay in diagnosis and treatment of TB in Uzbekistan and identify associated risk factors. METHODS: A cross-sectional study was performed on hospital patients with newly diagnosed TB. The time between the onset of respiratory symptoms and initiation of anti-TB treatment was assessed and delays were divided into patient, health system and total delays. Univariable and multivariable logistic regression analysis was used to evaluate determinants of diagnostic and treatment delay. RESULTS: Among 538 patients enrolled, the median delay from onset of symptoms until treatment with anti-TB drugs was 50 days. Analysis of the factors affecting health-seeking behaviour and timely treatment showed the presence of the patient factor. Self-medication was the first health-seeking action for 231 (43%) patients and proved to be a significant predictor of delay (p = 0.005), as well as coughing (p = 0.009), loss of weight (p = 0.001), and visiting private and primary healthcare facilities (p = 0.03 and p = 0.02, respectively). CONCLUSION: TB diagnostic and treatment delay was mainly contributed to by patient delay and should be reduced through increasing public awareness of TB symptoms and improving public health-seeking behaviour for timely initiation of anti-TB treatment. Efforts should be made to minimise irrational use of antibiotics and support interventions to restrict over-the-counter availability of antibiotics. |
format | Online Article Text |
id | pubmed-4248454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42484542014-12-02 Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study Belkina, Tatiana V Khojiev, Doniyor S Tillyashaykhov, Mirzagaleb N Tigay, Zinaida N Kudenov, Marat U Tebbens, Jurjen Duintjer Vlcek, Jiri BMC Infect Dis Research Article BACKGROUND: Early diagnosis and prompt effective therapy are crucial for the prevention of tuberculosis (TB) transmission, particularly in regions with high levels of multi-drug resistant TB. This study aimed to evaluate the extent of delay in diagnosis and treatment of TB in Uzbekistan and identify associated risk factors. METHODS: A cross-sectional study was performed on hospital patients with newly diagnosed TB. The time between the onset of respiratory symptoms and initiation of anti-TB treatment was assessed and delays were divided into patient, health system and total delays. Univariable and multivariable logistic regression analysis was used to evaluate determinants of diagnostic and treatment delay. RESULTS: Among 538 patients enrolled, the median delay from onset of symptoms until treatment with anti-TB drugs was 50 days. Analysis of the factors affecting health-seeking behaviour and timely treatment showed the presence of the patient factor. Self-medication was the first health-seeking action for 231 (43%) patients and proved to be a significant predictor of delay (p = 0.005), as well as coughing (p = 0.009), loss of weight (p = 0.001), and visiting private and primary healthcare facilities (p = 0.03 and p = 0.02, respectively). CONCLUSION: TB diagnostic and treatment delay was mainly contributed to by patient delay and should be reduced through increasing public awareness of TB symptoms and improving public health-seeking behaviour for timely initiation of anti-TB treatment. Efforts should be made to minimise irrational use of antibiotics and support interventions to restrict over-the-counter availability of antibiotics. BioMed Central 2014-11-25 /pmc/articles/PMC4248454/ /pubmed/25421106 http://dx.doi.org/10.1186/s12879-014-0624-y Text en © Belkina et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Belkina, Tatiana V Khojiev, Doniyor S Tillyashaykhov, Mirzagaleb N Tigay, Zinaida N Kudenov, Marat U Tebbens, Jurjen Duintjer Vlcek, Jiri Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title | Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title_full | Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title_fullStr | Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title_full_unstemmed | Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title_short | Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study |
title_sort | delay in the diagnosis and treatment of pulmonary tuberculosis in uzbekistan: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248454/ https://www.ncbi.nlm.nih.gov/pubmed/25421106 http://dx.doi.org/10.1186/s12879-014-0624-y |
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