Cargando…
Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria
Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chines...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248482/ https://www.ncbi.nlm.nih.gov/pubmed/25484900 http://dx.doi.org/10.1155/2014/959781 |
_version_ | 1782346810299252736 |
---|---|
author | Zhou, Yulin Ye, Lei Wang, Tiange Hong, Jie Bi, Yufang Zhang, Jie Xu, Baihui Sun, Jichao Huang, Xiaolin Xu, Min |
author_facet | Zhou, Yulin Ye, Lei Wang, Tiange Hong, Jie Bi, Yufang Zhang, Jie Xu, Baihui Sun, Jichao Huang, Xiaolin Xu, Min |
author_sort | Zhou, Yulin |
collection | PubMed |
description | Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A community-based cross-sectional study was performed among 3,346 Chinese adults (aged ≥ 40 years). Serum free triiodothyronine (FT3), free thyroxine (FT4), and TSH (thyroid stimulating hormone) were determined by chemiluminescent microparticle immunoassay. A single-void first morning urine sample was obtained for urinary albumin-creatinine ratio measurement. The prevalence of microalbuminuria decreased according to FT3 quartiles (13.2, 9.5, 8.6, and 8.2%, P for trend = 0.0005). A fully adjusted logistic regression analysis showed that high FT3 levels were associated with low prevalent microalbuminuria. The adjusted odds ratios for microalbuminuria were 0.61 (95% CI, 0.43–0.87, P = 0.007) when comparing the highest with the lowest quartile of FT3. The exclusion of participants with abnormal FT3 did not appreciably change the results (OR = 0.69, 95% CI, 0.49–0.98, P = 0.02). We concluded that serum FT3 levels, even within the normal range, were inversely associated with microalbuminuria in middle-aged and elderly Chinese adults. FT3 concentrations might play a role in the pathogenesis of microalbuminuria. |
format | Online Article Text |
id | pubmed-4248482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42484822014-12-07 Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria Zhou, Yulin Ye, Lei Wang, Tiange Hong, Jie Bi, Yufang Zhang, Jie Xu, Baihui Sun, Jichao Huang, Xiaolin Xu, Min Int J Endocrinol Research Article Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A community-based cross-sectional study was performed among 3,346 Chinese adults (aged ≥ 40 years). Serum free triiodothyronine (FT3), free thyroxine (FT4), and TSH (thyroid stimulating hormone) were determined by chemiluminescent microparticle immunoassay. A single-void first morning urine sample was obtained for urinary albumin-creatinine ratio measurement. The prevalence of microalbuminuria decreased according to FT3 quartiles (13.2, 9.5, 8.6, and 8.2%, P for trend = 0.0005). A fully adjusted logistic regression analysis showed that high FT3 levels were associated with low prevalent microalbuminuria. The adjusted odds ratios for microalbuminuria were 0.61 (95% CI, 0.43–0.87, P = 0.007) when comparing the highest with the lowest quartile of FT3. The exclusion of participants with abnormal FT3 did not appreciably change the results (OR = 0.69, 95% CI, 0.49–0.98, P = 0.02). We concluded that serum FT3 levels, even within the normal range, were inversely associated with microalbuminuria in middle-aged and elderly Chinese adults. FT3 concentrations might play a role in the pathogenesis of microalbuminuria. Hindawi Publishing Corporation 2014 2014-11-16 /pmc/articles/PMC4248482/ /pubmed/25484900 http://dx.doi.org/10.1155/2014/959781 Text en Copyright © 2014 Yulin Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Yulin Ye, Lei Wang, Tiange Hong, Jie Bi, Yufang Zhang, Jie Xu, Baihui Sun, Jichao Huang, Xiaolin Xu, Min Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title | Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title_full | Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title_fullStr | Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title_full_unstemmed | Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title_short | Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria |
title_sort | free triiodothyronine concentrations are inversely associated with microalbuminuria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248482/ https://www.ncbi.nlm.nih.gov/pubmed/25484900 http://dx.doi.org/10.1155/2014/959781 |
work_keys_str_mv | AT zhouyulin freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT yelei freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT wangtiange freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT hongjie freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT biyufang freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT zhangjie freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT xubaihui freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT sunjichao freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT huangxiaolin freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria AT xumin freetriiodothyronineconcentrationsareinverselyassociatedwithmicroalbuminuria |