Altered Serum Uric Acid Level in Lichen Planus Patients

BACKGROUND: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. OBJECTIVES: The principal aim of this study was to evaluate serum uric acid (U...

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Detalles Bibliográficos
Autores principales: Chakraborti, Goutam, Biswas, Rabindranath, Chakraborti, Sandip, Sen, Pradyot Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248490/
https://www.ncbi.nlm.nih.gov/pubmed/25484383
http://dx.doi.org/10.4103/0019-5154.143510
Descripción
Sumario:BACKGROUND: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. OBJECTIVES: The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients. METHODS: Serum UA levels were determined in 58 LP patients and 61 controls. RESULTS: Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease. CONCLUSIONS: The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring.

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