Novel Denisovan and Neanderthal Retroviruses

Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the huma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Adam, Huntley, Derek, Aiewsakun, Pakorn, Kanda, Ravinder K., Lynn, Claire, Tristem, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248912/
https://www.ncbi.nlm.nih.gov/pubmed/25142605
http://dx.doi.org/10.1128/JVI.01825-14
_version_ 1782346850214346752
author Lee, Adam
Huntley, Derek
Aiewsakun, Pakorn
Kanda, Ravinder K.
Lynn, Claire
Tristem, Michael
author_facet Lee, Adam
Huntley, Derek
Aiewsakun, Pakorn
Kanda, Ravinder K.
Lynn, Claire
Tristem, Michael
author_sort Lee, Adam
collection PubMed
description Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.
format Online
Article
Text
id pubmed-4248912
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-42489122014-12-18 Novel Denisovan and Neanderthal Retroviruses Lee, Adam Huntley, Derek Aiewsakun, Pakorn Kanda, Ravinder K. Lynn, Claire Tristem, Michael J Virol Genetic Diversity and Evolution Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids. American Society for Microbiology 2014-11 /pmc/articles/PMC4248912/ /pubmed/25142605 http://dx.doi.org/10.1128/JVI.01825-14 Text en Copyright © 2014 Lee et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Genetic Diversity and Evolution
Lee, Adam
Huntley, Derek
Aiewsakun, Pakorn
Kanda, Ravinder K.
Lynn, Claire
Tristem, Michael
Novel Denisovan and Neanderthal Retroviruses
title Novel Denisovan and Neanderthal Retroviruses
title_full Novel Denisovan and Neanderthal Retroviruses
title_fullStr Novel Denisovan and Neanderthal Retroviruses
title_full_unstemmed Novel Denisovan and Neanderthal Retroviruses
title_short Novel Denisovan and Neanderthal Retroviruses
title_sort novel denisovan and neanderthal retroviruses
topic Genetic Diversity and Evolution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248912/
https://www.ncbi.nlm.nih.gov/pubmed/25142605
http://dx.doi.org/10.1128/JVI.01825-14
work_keys_str_mv AT leeadam noveldenisovanandneanderthalretroviruses
AT huntleyderek noveldenisovanandneanderthalretroviruses
AT aiewsakunpakorn noveldenisovanandneanderthalretroviruses
AT kandaravinderk noveldenisovanandneanderthalretroviruses
AT lynnclaire noveldenisovanandneanderthalretroviruses
AT tristemmichael noveldenisovanandneanderthalretroviruses

Ejemplares similares