Cargando…

AZD5363 Inhibits Inflammatory Synergy between Interleukin-17 and Insulin/Insulin-Like Growth Factor 1

In the United States, one-third of population is affected by obesity and almost 29 million people are suffering from type 2 diabetes. Obese people have elevated serum levels of insulin, insulin-like growth factor 1 (IGF1), and interleukin-17 (IL-17). Insulin and IGF1 are known to enhance IL-17-induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Chong, Zhang, Qiuyang, Liu, Sen, Lambrechts, Mark, Qu, Yine, You, Zongbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249256/ https://www.ncbi.nlm.nih.gov/pubmed/25520943 http://dx.doi.org/10.3389/fonc.2014.00343

Ejemplares similares

Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice
por: Qu, Yine, et al.
Publicado: (2016)

A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes
por: Patra, Tapas, et al.
Publicado: (2020)

Safety and tolerability of AZD5363 in Japanese patients with advanced solid tumors
por: Tamura, Kenji, et al.
Publicado: (2016)

T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma
por: Zhong, Sheng, et al.
Publicado: (2019)

A Phase 1, open-label, multicentre study to compare the capsule and tablet formulations of AZD5363 and explore the effect of food on the pharmacokinetic exposure, safety and tolerability of AZD5363 in patients with advanced solid malignancies: OAK
por: Dean, Emma, et al.
Publicado: (2018)

Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor
por: Liu, Sen, et al.
Publicado: (2016)

Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells
por: Li, Qingli, et al.
Publicado: (2014)

Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression
por: Guo, Na, et al.
Publicado: (2019)

Targeting mitochondrial dynamics by AZD5363 in triple-negative breast cancer MDA-MB-231 cell–derived spheres
por: Fu, Yingqiang, et al.
Publicado: (2023)

Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways
por: Mejía-Rodríguez, Rosalinda, et al.
Publicado: (2023)

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses
por: Xie, Zhaohui, et al.
Publicado: (2015)

Expression of interleukin-17RC protein in normal human tissues
por: Ge, Dongxia, et al.
Publicado: (2008)

A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer
por: Kolinsky, M.P., et al.
Publicado: (2020)

ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer
por: Crabb, Simon J., et al.
Publicado: (2017)

Modifying Effects of Glucose and Insulin/Insulin-Like Growth Factors on Colon Cancer Cells
por: Berk, Şeyda, et al.
Publicado: (2021)

Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models
por: CRAFTER, CLAIRE, et al.
Publicado: (2015)

A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type
por: ZHANG, YUNCHENG, et al.
Publicado: (2016)

Hallmarks of cancer: The insulin-like growth factors perspective
por: Werner, Haim, et al.
Publicado: (2022)

Insulin Resistance and Serum Levels of Interleukin-17 and Interleukin-18 in Normal Pregnancy
por: Jahromi, Abdolreza Sotoodeh, et al.
Publicado: (2014)

Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis
por: Li, Qingli, et al.
Publicado: (2013)

Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk
por: Shi, Joy, et al.
Publicado: (2016)

The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere
por: Li, Jing, et al.
Publicado: (2013)

Aminomethylphosphonic Acid and Methoxyacetic Acid Induce Apoptosis in Prostate Cancer Cells
por: Parajuli, Keshab R., et al.
Publicado: (2015)

Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model
por: Parajuli, Keshab Raj, et al.
Publicado: (2016)

Interleukin 17 in early invasive breast cancer
por: Popović, Marina, et al.
Publicado: (2023)

Insulin-like growth factor binding protein 5: Diverse roles in cancer
por: Waters, Jennifer A., et al.
Publicado: (2022)

Type 1 insulin-like growth factor receptor targeted therapies in pediatric cancer
por: Wagner, Michael J., et al.
Publicado: (2013)

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer
por: Girondel, Charlotte, et al.
Publicado: (2021)

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways
por: Werner, Haim, et al.
Publicado: (2016)

Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells
por: Lehman, Christine E., et al.
Publicado: (2019)

Associations Between Circulating Insulin-Like Growth Factor 1 and Mortality in Women With Invasive Breast Cancer
por: Zhu, Yifei, et al.
Publicado: (2020)

Synergy of Losartan and chemotherapy for patients with cholangiocarcinoma: A propensity score-matched analysis
por: Li, Qing, et al.
Publicado: (2022)

Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents
por: Huang, Rae-Chi, et al.
Publicado: (2009)

A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility
por: Cheraghpour, Makan, et al.
Publicado: (2023)

Insulin-like growth factor 2 hypermethylation in peripheral blood leukocytes and colorectal cancer risk and prognosis: a propensity score analysis
por: Sun, HongRu, et al.
Publicado: (2023)

Synergy between adiponectin and interleukin-1β on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes
por: Lee, Yeon-Ah, et al.
Publicado: (2012)

The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy
por: Vigneri, Paolo Giovanni, et al.
Publicado: (2015)

Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma
por: Tirrò, Elena, et al.
Publicado: (2021)

Interleukin-17 in human inflammatory diseases
por: Shabgah, Arezoo Gowhari, et al.
Publicado: (2014)

Serum interleukin 17A and interleukin 17F in children with inflammatory bowel disease
por: Krawiec, Paulina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1n47d5lug3ne82s0a83rp3maj3