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Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade

Ketamine is a N-methyl-D-aspartate receptor (NMDAR) antagonist that produces rapid antidepressant responses in individuals with major depressive disorder. The antidepressant action of ketamine has been linked to blocking NMDAR activation at rest, which inhibits eukaryotic elongation factor 2 kinase...

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Detalles Bibliográficos
Autores principales:	Nosyreva, Elena, Autry, Anita E., Kavalali, Ege T., Monteggia, Lisa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249453/ https://www.ncbi.nlm.nih.gov/pubmed/25520615 http://dx.doi.org/10.3389/fnmol.2014.00094

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