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Autistic traits modulate frontostriatal connectivity during processing of rewarding faces
Deficits in facial mimicry have been widely reported in autism. Some studies have suggested that these deficits are restricted to spontaneous mimicry and do not extend to volitional mimicry. We bridge these apparently inconsistent observations by testing the impact of reward value on neural indices...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249479/ https://www.ncbi.nlm.nih.gov/pubmed/24493838 http://dx.doi.org/10.1093/scan/nsu010 |
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author | Sims, Thomas B. Neufeld, Janina Johnstone, Tom Chakrabarti, Bhismadev |
author_facet | Sims, Thomas B. Neufeld, Janina Johnstone, Tom Chakrabarti, Bhismadev |
author_sort | Sims, Thomas B. |
collection | PubMed |
description | Deficits in facial mimicry have been widely reported in autism. Some studies have suggested that these deficits are restricted to spontaneous mimicry and do not extend to volitional mimicry. We bridge these apparently inconsistent observations by testing the impact of reward value on neural indices of mimicry and how autistic traits modulate this impact. Neutral faces were conditioned with high and low reward. Subsequently, functional connectivity between the ventral striatum (VS) and inferior frontal gyrus (IFG) was measured while neurotypical adults (n = 30) watched happy expressions made by these conditioned faces. We found greater VS–IFG connectivity in response to high reward vs low reward happy faces. This difference was negatively proportional to autistic traits, suggesting that reduced spontaneous mimicry of social stimuli seen in autism, may be related to a failure in the modulation of the mirror system by the reward system rather than a circumscribed deficit in the mirror system. |
format | Online Article Text |
id | pubmed-4249479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42494792014-12-04 Autistic traits modulate frontostriatal connectivity during processing of rewarding faces Sims, Thomas B. Neufeld, Janina Johnstone, Tom Chakrabarti, Bhismadev Soc Cogn Affect Neurosci Original Articles Deficits in facial mimicry have been widely reported in autism. Some studies have suggested that these deficits are restricted to spontaneous mimicry and do not extend to volitional mimicry. We bridge these apparently inconsistent observations by testing the impact of reward value on neural indices of mimicry and how autistic traits modulate this impact. Neutral faces were conditioned with high and low reward. Subsequently, functional connectivity between the ventral striatum (VS) and inferior frontal gyrus (IFG) was measured while neurotypical adults (n = 30) watched happy expressions made by these conditioned faces. We found greater VS–IFG connectivity in response to high reward vs low reward happy faces. This difference was negatively proportional to autistic traits, suggesting that reduced spontaneous mimicry of social stimuli seen in autism, may be related to a failure in the modulation of the mirror system by the reward system rather than a circumscribed deficit in the mirror system. Oxford University Press 2014-12 2014-03-13 /pmc/articles/PMC4249479/ /pubmed/24493838 http://dx.doi.org/10.1093/scan/nsu010 Text en © The Author (2014). Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Sims, Thomas B. Neufeld, Janina Johnstone, Tom Chakrabarti, Bhismadev Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title | Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title_full | Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title_fullStr | Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title_full_unstemmed | Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title_short | Autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
title_sort | autistic traits modulate frontostriatal connectivity during processing of rewarding faces |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249479/ https://www.ncbi.nlm.nih.gov/pubmed/24493838 http://dx.doi.org/10.1093/scan/nsu010 |
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