Inhibition of Osteoclastogenesis and Inflammatory Bone Resorption by Targeting BET Proteins and Epigenetic Regulation

Emerging evidence suggests that RANKL-induced changes in chromatin state are important for osteoclastogenesis, but these epigenetic mechanisms are not well understood and have not been therapeutically targeted. In this study we find that the small molecule I-BET151 that targets bromo and extra-termi...

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Detalles Bibliográficos
Autores principales: Park-Min, Kyung-Hyun, Lim, Elisha, Lee, Min Joon, Park, Sung Ho, Giannopoulos, Eugenia, Yarilina, Anna, van der Meulen, Marjolein, Zhao, Baohong, Smithers, Nicholas, Witherington, Jason, Lee, Kevin, Tak, Paul P., Prinjha, Rab K., Ivashkiv, Lionel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249944/
https://www.ncbi.nlm.nih.gov/pubmed/25391636
http://dx.doi.org/10.1038/ncomms6418

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