Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice

OBJECTIVE: The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors...

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Detalles Bibliográficos
Autores principales: Höllerhage, Matthias, Deck, Roman, De Andrade, Anderson, Respondek, Gesine, Xu, Hong, Rösler, Thomas W., Salama, Mohamed, Carlsson, Thomas, Yamada, Elizabeth S., Gad El Hak, Seham A., Goedert, Michel, Oertel, Wolfgang H., Höglinger, Günter U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249965/
https://www.ncbi.nlm.nih.gov/pubmed/25437199
http://dx.doi.org/10.1371/journal.pone.0113557

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