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Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers

The transport activity of human mitochondrial aspartate/glutamate carriers is central to the malate–aspartate shuttle, urea cycle, gluconeogenesis and myelin synthesis. They have a unique three-domain structure, comprising a calcium-regulated N-terminal domain with eight EF-hands, a mitochondrial ca...

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Detalles Bibliográficos
Autores principales:	Thangaratnarajah, Chancievan, Ruprecht, Jonathan J., Kunji, Edmund R. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250520/ https://www.ncbi.nlm.nih.gov/pubmed/25410934 http://dx.doi.org/10.1038/ncomms6491

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