Cargando…

T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

T cells modified with chimeric antigen receptor are an attractive strategy to treat Epstein-Barr virus (EBV) associated malignancies. The EBV latent membrane protein 1 (LMP1) is a 66-KD integral membrane protein encoded by EBV that consists of transmembrane-spanning loops. Previously, we have identi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Xiaojun, Zhou, Yan, Li, Wenjie, Tang, Qi, Chen, Renjie, Zhu, Jin, Feng, Zhenqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editorial Department of Journal of Biomedical Research 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250525/ https://www.ncbi.nlm.nih.gov/pubmed/25469116 http://dx.doi.org/10.7555/JBR.28.20140066

Ejemplares similares

CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo
por: Tang, Xiaojun, et al.
Publicado: (2019)

In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma()
por: Ye, Qing, et al.
Publicado: (2019)

Molecular Screening of Nasopharyngeal Carcinoma: Detection of LMP-1, LMP-2 Gene Expression in Vietnamese Nasopharyngeal Swab Samples
por: Lao, Thuan Duc, et al.
Publicado: (2019)

Novel Bifunctional Affibody Molecules with Specific Binding to Both EBV LMP1 and LMP2 for Targeted Therapy of Nasopharyngeal Carcinoma
por: Kamara, Saidu, et al.
Publicado: (2023)

New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
por: Shair, Kathy H. Y., et al.
Publicado: (2018)

Positive regulation of TAZ expression by EBV-LMP1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma
por: He, Jiang, et al.
Publicado: (2016)

LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)
por: Mao, Yuan, et al.
Publicado: (2012)

Immunoassay for LMP1 in nasopharyngeal tissue based on surface-enhanced Raman scattering
por: Chen, Yanping, et al.
Publicado: (2012)

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis
por: French, Timothy, et al.
Publicado: (2021)

Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo
por: Lin, Mei-Chun, et al.
Publicado: (2017)

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma
por: Cai, Ting-Ting, et al.
Publicado: (2017)

Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A
por: Du, Zi-Ming, et al.
Publicado: (2011)

Preclinical study of LMP1-RNAi-based anti-tumor therapy in EBV-positive nasopharyngeal carcinoma
por: Yuan, Qi, et al.
Publicado: (2023)

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes
por: Aga, M, et al.
Publicado: (2014)

LMP1‐positive extracellular vesicles promote radioresistance in nasopharyngeal carcinoma cells through P38 MAPK signaling
por: Zhang, Zhibao, et al.
Publicado: (2019)

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
por: Du, Sheng-hong, et al.
Publicado: (2021)

Transcriptome Changes Induced by Epstein-Barr Virus LMP1 and LMP2A in Transgenic Lymphocytes and Lymphoma
por: Shair, Kathy H. Y., et al.
Publicado: (2012)

Molecular Screening for Epstein-Barr virus (EBV): Detection of Genomic EBNA-1, EBNA-2, LMP-1, LMP-2 Among Vietnamese Patients with Nasopharyngeal Brush Samples
por: Lao, Thuan Duc, et al.
Publicado: (2017)

A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene
por: Yang, Lifang, et al.
Publicado: (2010)

EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer
por: Wakae, Kousho, et al.
Publicado: (2020)

Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines
por: Sun, Liying, et al.
Publicado: (2018)

Epstein–Barr Virus LMP1 Induces Soluble PD-L1 in Nasopharyngeal Carcinoma
por: Kase, Kina, et al.
Publicado: (2021)

The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells
por: Zeng, Mei, et al.
Publicado: (2020)

Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma
por: Rutkowska, Justyna, et al.
Publicado: (2023)

Generating CTLs against the subdominant EBV LMP antigens by transit expression of an A20 inhibitor with EBV LMP proteins in human DCs
por: Hong, Bangxing, et al.
Publicado: (2011)

Epstein-Barr Virus LMP2A Reduces Hyperactivation Induced by LMP1 to Restore Normal B Cell Phenotype in Transgenic Mice
por: Vrazo, Alexandra C., et al.
Publicado: (2012)

Characterization of human Fab antibody fragments specific to LMP1 (HLEAFab) in nasopharyngeal carcinoma for potential molecular diagnosis and therapeutic applications
por: ZHANG, DAWEI, et al.
Publicado: (2013)

Proteomic identification of the tyrosine phosphatase SHP1 as a novel LMP1 interaction partner, which mediates autoregulation of LMP1 signaling
por: Griese, J, et al.
Publicado: (2009)

LMP1-EBV Gene Deletion Mutations and HLA Genotypes of Nasopharyngeal Cancer Patients in Vietnam
por: Trinh, Cua Thi Hong, et al.
Publicado: (2023)

New Look of EBV LMP1 Signaling Landscape
por: Wang, Ling, et al.
Publicado: (2021)

Measurement of CD8(+) and CD4(+) T Cell Frequencies Specific for EBV LMP1 and LMP2a Using mRNA-Transfected DCs
por: Sohn, Dae-Hee, et al.
Publicado: (2015)

Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma
por: Zhu, Shanli, et al.
Publicado: (2020)

Id1 Interacts and Stabilizes the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) in Nasopharyngeal Epithelial Cells
por: Hau, Pok Man, et al.
Publicado: (2011)

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy
por: Xiao, L, et al.
Publicado: (2014)

The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users()
por: Cui, Qian, et al.
Publicado: (2010)

Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome()
por: Tertipis, Nikolaos, et al.
Publicado: (2015)

c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and in vivo
por: Huang, Xiaochen, et al.
Publicado: (2022)

Long-term Outcome of Extranodal NK/T Cell Lymphoma Patients Treated With Postremission Therapy Using EBV LMP1 and LMP2a-specific CTLs
por: Cho, Seok-Goo, et al.
Publicado: (2015)

Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection
por: Yang, Lan, et al.
Publicado: (2017)

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma
por: Wang, Zifeng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l03q8n4dkrub7kgpkciiplsq3q