Limonoid and Steroidal Saponin from Azadirachta indica

A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide (1), and a new C21 steroidal saponin, 2α,4α-dihydroxy-pregn-5-en-16-one-3α-O-d-glucopyranoside (2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were eluci...

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Detalles Bibliográficos
Autores principales: Liu, Lu, Zhao, Yun-Li, Cheng, Gui-Guang, Chen, Ying-Ying, Qin, Xu-Jie, Song, Chang-Wei, Yang, Xing-Wei, Liu, Ya-Ping, Luo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250567/
https://www.ncbi.nlm.nih.gov/pubmed/25381190
http://dx.doi.org/10.1007/s13659-014-0042-2
Descripción
Sumario:A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide (1), and a new C21 steroidal saponin, 2α,4α-dihydroxy-pregn-5-en-16-one-3α-O-d-glucopyranoside (2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their antibacterial activities against six bacterial strains. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0042-2) contains supplementary material, which is available to authorized users.

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