Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

Crystalline structures activate the NLRP3 inflammasome, leading to the production of IL-1β, however, the molecular interactions responsible for NLRP3 activation are not fully understood. Cathepsin B release from the ruptured phagolysosome and potassium ion efflux have been suggested to be critical f...

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Detalles Bibliográficos
Autores principales: Hari, Aswin, Zhang, Yifei, Tu, Zhongyuan, Detampel, Pascal, Stenner, Melanie, Ganguly, Anutosh, Shi, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250918/
https://www.ncbi.nlm.nih.gov/pubmed/25445147
http://dx.doi.org/10.1038/srep07281

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