Ribosomopathies: Mechanisms of Disease

Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosoma...

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Detalles Bibliográficos
Autores principales: Nakhoul, Hani, Ke, Jiangwei, Zhou, Xiang, Liao, Wenjuan, Zeng, Shelya X, Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251057/
https://www.ncbi.nlm.nih.gov/pubmed/25512719
http://dx.doi.org/10.4137/CMBD.S16952
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author Nakhoul, Hani
Ke, Jiangwei
Zhou, Xiang
Liao, Wenjuan
Zeng, Shelya X
Lu, Hua
author_facet Nakhoul, Hani
Ke, Jiangwei
Zhou, Xiang
Liao, Wenjuan
Zeng, Shelya X
Lu, Hua
author_sort Nakhoul, Hani
collection PubMed
description Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information.
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spelling pubmed-42510572014-12-15 Ribosomopathies: Mechanisms of Disease Nakhoul, Hani Ke, Jiangwei Zhou, Xiang Liao, Wenjuan Zeng, Shelya X Lu, Hua Clin Med Insights Blood Disord Review Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information. Libertas Academica 2014-08-14 /pmc/articles/PMC4251057/ /pubmed/25512719 http://dx.doi.org/10.4137/CMBD.S16952 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Nakhoul, Hani
Ke, Jiangwei
Zhou, Xiang
Liao, Wenjuan
Zeng, Shelya X
Lu, Hua
Ribosomopathies: Mechanisms of Disease
title Ribosomopathies: Mechanisms of Disease
title_full Ribosomopathies: Mechanisms of Disease
title_fullStr Ribosomopathies: Mechanisms of Disease
title_full_unstemmed Ribosomopathies: Mechanisms of Disease
title_short Ribosomopathies: Mechanisms of Disease
title_sort ribosomopathies: mechanisms of disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251057/
https://www.ncbi.nlm.nih.gov/pubmed/25512719
http://dx.doi.org/10.4137/CMBD.S16952
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