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Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors suc...

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Autores principales: Pacheco, Guillermo Valencia, Cruz, Darig Cámara, González Herrera, Lizbeth J, Pérez Mendoza, Gerardo J, Adrián Amaro, Guadalupe I, Nakazawa Ueji, Yumi E, Angulo Ramírez, Angélica V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251061/
https://www.ncbi.nlm.nih.gov/pubmed/25512712
http://dx.doi.org/10.4137/GEG.S16707
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author Pacheco, Guillermo Valencia
Cruz, Darig Cámara
González Herrera, Lizbeth J
Pérez Mendoza, Gerardo J
Adrián Amaro, Guadalupe I
Nakazawa Ueji, Yumi E
Angulo Ramírez, Angélica V
author_facet Pacheco, Guillermo Valencia
Cruz, Darig Cámara
González Herrera, Lizbeth J
Pérez Mendoza, Gerardo J
Adrián Amaro, Guadalupe I
Nakazawa Ueji, Yumi E
Angulo Ramírez, Angélica V
author_sort Pacheco, Guillermo Valencia
collection PubMed
description Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease.
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spelling pubmed-42510612014-12-15 Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico Pacheco, Guillermo Valencia Cruz, Darig Cámara González Herrera, Lizbeth J Pérez Mendoza, Gerardo J Adrián Amaro, Guadalupe I Nakazawa Ueji, Yumi E Angulo Ramírez, Angélica V Genet Epigenet Original Research Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease. Libertas Academica 2014-07-22 /pmc/articles/PMC4251061/ /pubmed/25512712 http://dx.doi.org/10.4137/GEG.S16707 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Pacheco, Guillermo Valencia
Cruz, Darig Cámara
González Herrera, Lizbeth J
Pérez Mendoza, Gerardo J
Adrián Amaro, Guadalupe I
Nakazawa Ueji, Yumi E
Angulo Ramírez, Angélica V
Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title_full Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title_fullStr Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title_full_unstemmed Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title_short Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
title_sort copy number variation of tlr-7 gene and its association with the development of systemic lupus erythematosus in female patients from yucatan mexico
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251061/
https://www.ncbi.nlm.nih.gov/pubmed/25512712
http://dx.doi.org/10.4137/GEG.S16707
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