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Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors suc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251061/ https://www.ncbi.nlm.nih.gov/pubmed/25512712 http://dx.doi.org/10.4137/GEG.S16707 |
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author | Pacheco, Guillermo Valencia Cruz, Darig Cámara González Herrera, Lizbeth J Pérez Mendoza, Gerardo J Adrián Amaro, Guadalupe I Nakazawa Ueji, Yumi E Angulo Ramírez, Angélica V |
author_facet | Pacheco, Guillermo Valencia Cruz, Darig Cámara González Herrera, Lizbeth J Pérez Mendoza, Gerardo J Adrián Amaro, Guadalupe I Nakazawa Ueji, Yumi E Angulo Ramírez, Angélica V |
author_sort | Pacheco, Guillermo Valencia |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease. |
format | Online Article Text |
id | pubmed-4251061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-42510612014-12-15 Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico Pacheco, Guillermo Valencia Cruz, Darig Cámara González Herrera, Lizbeth J Pérez Mendoza, Gerardo J Adrián Amaro, Guadalupe I Nakazawa Ueji, Yumi E Angulo Ramírez, Angélica V Genet Epigenet Original Research Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease. Libertas Academica 2014-07-22 /pmc/articles/PMC4251061/ /pubmed/25512712 http://dx.doi.org/10.4137/GEG.S16707 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Pacheco, Guillermo Valencia Cruz, Darig Cámara González Herrera, Lizbeth J Pérez Mendoza, Gerardo J Adrián Amaro, Guadalupe I Nakazawa Ueji, Yumi E Angulo Ramírez, Angélica V Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title | Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title_full | Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title_fullStr | Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title_full_unstemmed | Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title_short | Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico |
title_sort | copy number variation of tlr-7 gene and its association with the development of systemic lupus erythematosus in female patients from yucatan mexico |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251061/ https://www.ncbi.nlm.nih.gov/pubmed/25512712 http://dx.doi.org/10.4137/GEG.S16707 |
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