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Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia
Although the association between obesity and hypertension is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity (RSNA) compared...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251291/ https://www.ncbi.nlm.nih.gov/pubmed/25520669 http://dx.doi.org/10.3389/fphys.2014.00469 |
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author | Barzel, Benjamin Weir, Jacquelyn M. Meikle, Peter J. Burke, Sandra L. Armitage, James A. Head, Geoffrey A. |
author_facet | Barzel, Benjamin Weir, Jacquelyn M. Meikle, Peter J. Burke, Sandra L. Armitage, James A. Head, Geoffrey A. |
author_sort | Barzel, Benjamin |
collection | PubMed |
description | Although the association between obesity and hypertension is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity (RSNA) compared to rabbits on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with hypertension we compared plasma insulin, leptin, and lipid profiles in male New Zealand White rabbits fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), ceramide and cholesteryl esters (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma insulin and glucose increased within the first 3 days of the diet in HFD rabbits (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and Ceramide at week 3 did not differ between groups (P > 0.05). Our data show plasma insulin increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the hypertension in this animal model. |
format | Online Article Text |
id | pubmed-4251291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42512912014-12-17 Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia Barzel, Benjamin Weir, Jacquelyn M. Meikle, Peter J. Burke, Sandra L. Armitage, James A. Head, Geoffrey A. Front Physiol Physiology Although the association between obesity and hypertension is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity (RSNA) compared to rabbits on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with hypertension we compared plasma insulin, leptin, and lipid profiles in male New Zealand White rabbits fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), ceramide and cholesteryl esters (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma insulin and glucose increased within the first 3 days of the diet in HFD rabbits (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and Ceramide at week 3 did not differ between groups (P > 0.05). Our data show plasma insulin increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the hypertension in this animal model. Frontiers Media S.A. 2014-12-02 /pmc/articles/PMC4251291/ /pubmed/25520669 http://dx.doi.org/10.3389/fphys.2014.00469 Text en Copyright © 2014 Barzel, Weir, Meikle, Burke, Armitage and Head. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Barzel, Benjamin Weir, Jacquelyn M. Meikle, Peter J. Burke, Sandra L. Armitage, James A. Head, Geoffrey A. Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title | Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title_full | Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title_fullStr | Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title_full_unstemmed | Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title_short | Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
title_sort | short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251291/ https://www.ncbi.nlm.nih.gov/pubmed/25520669 http://dx.doi.org/10.3389/fphys.2014.00469 |
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