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Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics

Thousands of samples for pharmacogenetic tests have been analysed in our laboratory since its establishment. In this article we describe some of the most interesting cases of CYP poor metabolisers associated with adverse reactions to psychotropic drugs. Prevention of disease/illness, including Adver...

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Autores principales: Piatkov, Irina, Jones, Trudi, McLean, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251377/
https://www.ncbi.nlm.nih.gov/pubmed/25562357
http://dx.doi.org/10.3390/jpm2040149
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author Piatkov, Irina
Jones, Trudi
McLean, Mark
author_facet Piatkov, Irina
Jones, Trudi
McLean, Mark
author_sort Piatkov, Irina
collection PubMed
description Thousands of samples for pharmacogenetic tests have been analysed in our laboratory since its establishment. In this article we describe some of the most interesting cases of CYP poor metabolisers associated with adverse reactions to psychotropic drugs. Prevention of disease/illness, including Adverse Drug Reaction (ADR), is an aim of modern medicine. Scientific data supports the fact that evaluation of drug toxicology includes several factors, one of which is genetic variations in pharmacodynamics and pharmacokinetics of drug pathways. These variations are only a part of toxicity evaluation, however, even if it would help to prevent only a small percentage of patients from suffering adverse drug reactions, especially life threatening ADRs, pharmacogenetic testing should play a significant role in any modern psychopharmacologic practice. Medical practitioners should also consider the use of other medications or alternative dosing strategies for drugs in patients identified as altered metabolisers. This will promise not only better and safer treatments for patients, but also potentially lowering overall healthcare costs.
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spelling pubmed-42513772014-12-15 Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics Piatkov, Irina Jones, Trudi McLean, Mark J Pers Med Case Report Thousands of samples for pharmacogenetic tests have been analysed in our laboratory since its establishment. In this article we describe some of the most interesting cases of CYP poor metabolisers associated with adverse reactions to psychotropic drugs. Prevention of disease/illness, including Adverse Drug Reaction (ADR), is an aim of modern medicine. Scientific data supports the fact that evaluation of drug toxicology includes several factors, one of which is genetic variations in pharmacodynamics and pharmacokinetics of drug pathways. These variations are only a part of toxicity evaluation, however, even if it would help to prevent only a small percentage of patients from suffering adverse drug reactions, especially life threatening ADRs, pharmacogenetic testing should play a significant role in any modern psychopharmacologic practice. Medical practitioners should also consider the use of other medications or alternative dosing strategies for drugs in patients identified as altered metabolisers. This will promise not only better and safer treatments for patients, but also potentially lowering overall healthcare costs. MDPI 2012-10-01 /pmc/articles/PMC4251377/ /pubmed/25562357 http://dx.doi.org/10.3390/jpm2040149 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Case Report
Piatkov, Irina
Jones, Trudi
McLean, Mark
Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title_full Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title_fullStr Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title_full_unstemmed Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title_short Cases of Adverse Reaction to Psychotropic Drugs and Possible Association with Pharmacogenetics
title_sort cases of adverse reaction to psychotropic drugs and possible association with pharmacogenetics
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251377/
https://www.ncbi.nlm.nih.gov/pubmed/25562357
http://dx.doi.org/10.3390/jpm2040149
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