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Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus

Non-typeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus are closely related bacteria that reside in the upper respiratory tract. NTHi is associated with respiratory tract infections that frequently result in antibiotic prescription whilst H. haemolyticus is rarely associated with dis...

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Autores principales: Pickering, Janessa, Richmond, Peter C., Kirkham, Lea-Ann S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251515/
https://www.ncbi.nlm.nih.gov/pubmed/25520712
http://dx.doi.org/10.3389/fmicb.2014.00664
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author Pickering, Janessa
Richmond, Peter C.
Kirkham, Lea-Ann S.
author_facet Pickering, Janessa
Richmond, Peter C.
Kirkham, Lea-Ann S.
author_sort Pickering, Janessa
collection PubMed
description Non-typeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus are closely related bacteria that reside in the upper respiratory tract. NTHi is associated with respiratory tract infections that frequently result in antibiotic prescription whilst H. haemolyticus is rarely associated with disease. NTHi and H. haemolyticus can be indistinguishable by traditional culture methods and molecular differentiation has proven difficult. This current review chronologically summarizes the molecular approaches that have been developed for differentiation of NTHi from H. haemolyticus, highlighting the advantages and disadvantages of each target and/or technique. We also provide suggestions for the development of new tools that would be suitable for clinical and research laboratories.
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spelling pubmed-42515152014-12-17 Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus Pickering, Janessa Richmond, Peter C. Kirkham, Lea-Ann S. Front Microbiol Public Health Non-typeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus are closely related bacteria that reside in the upper respiratory tract. NTHi is associated with respiratory tract infections that frequently result in antibiotic prescription whilst H. haemolyticus is rarely associated with disease. NTHi and H. haemolyticus can be indistinguishable by traditional culture methods and molecular differentiation has proven difficult. This current review chronologically summarizes the molecular approaches that have been developed for differentiation of NTHi from H. haemolyticus, highlighting the advantages and disadvantages of each target and/or technique. We also provide suggestions for the development of new tools that would be suitable for clinical and research laboratories. Frontiers Media S.A. 2014-12-02 /pmc/articles/PMC4251515/ /pubmed/25520712 http://dx.doi.org/10.3389/fmicb.2014.00664 Text en Copyright © 2014 Pickering, Richmond and Kirkham. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Pickering, Janessa
Richmond, Peter C.
Kirkham, Lea-Ann S.
Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title_full Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title_fullStr Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title_full_unstemmed Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title_short Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus
title_sort molecular tools for differentiation of non-typeable haemophilus influenzae from haemophilus haemolyticus
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251515/
https://www.ncbi.nlm.nih.gov/pubmed/25520712
http://dx.doi.org/10.3389/fmicb.2014.00664
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