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Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells

[Image: see text] Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of...

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Autores principales: Sunassee, Suthananda N., Ransom, Tanya, Henrich, Curtis J., Beutler, John A., Covell, David G., McMahon, James B., Gustafson, Kirk R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251534/
https://www.ncbi.nlm.nih.gov/pubmed/25338277
http://dx.doi.org/10.1021/np500556t
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author Sunassee, Suthananda N.
Ransom, Tanya
Henrich, Curtis J.
Beutler, John A.
Covell, David G.
McMahon, James B.
Gustafson, Kirk R.
author_facet Sunassee, Suthananda N.
Ransom, Tanya
Henrich, Curtis J.
Beutler, John A.
Covell, David G.
McMahon, James B.
Gustafson, Kirk R.
author_sort Sunassee, Suthananda N.
collection PubMed
description [Image: see text] Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of the marine sponge Corticium niger provided two new steroidal alkaloids, plakinamines N (1) and O (2), along with two known compounds of the plakinamine class (3, 4). The structures of these compounds were elucidated by interpretation of combined MS and NMR spectroscopic data. Plakinamines N (1), O (2), and J (4) were tested for antiproliferative activity in the NCI-60 screen, and they showed enhanced inhibitory effects against all of the colon cell lines with mean GI(50) values of 11.5, 2.4, and 1.4 μM, respectively.
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spelling pubmed-42515342015-10-22 Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells Sunassee, Suthananda N. Ransom, Tanya Henrich, Curtis J. Beutler, John A. Covell, David G. McMahon, James B. Gustafson, Kirk R. J Nat Prod [Image: see text] Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of the marine sponge Corticium niger provided two new steroidal alkaloids, plakinamines N (1) and O (2), along with two known compounds of the plakinamine class (3, 4). The structures of these compounds were elucidated by interpretation of combined MS and NMR spectroscopic data. Plakinamines N (1), O (2), and J (4) were tested for antiproliferative activity in the NCI-60 screen, and they showed enhanced inhibitory effects against all of the colon cell lines with mean GI(50) values of 11.5, 2.4, and 1.4 μM, respectively. American Chemical Society and American Society of Pharmacognosy 2014-10-22 2014-11-26 /pmc/articles/PMC4251534/ /pubmed/25338277 http://dx.doi.org/10.1021/np500556t Text en Copyright © 2014 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sunassee, Suthananda N.
Ransom, Tanya
Henrich, Curtis J.
Beutler, John A.
Covell, David G.
McMahon, James B.
Gustafson, Kirk R.
Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title_full Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title_fullStr Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title_full_unstemmed Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title_short Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells
title_sort steroidal alkaloids from the marine sponge corticium niger that inhibit growth of human colon carcinoma cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251534/
https://www.ncbi.nlm.nih.gov/pubmed/25338277
http://dx.doi.org/10.1021/np500556t
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