Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists

[Image: see text] A small library of synthetic (−)-palmyrolide A diastereomers, analogues, and acyclic precursors have been examined with respect to their interaction with voltage-gated sodium channels (VGSCs). Toward this goal, the ability of (−)-palmyrolide A and analogues to antagonize veratridin...

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Detalles Bibliográficos
Autores principales: Mehrotra, Suneet, Duggan, Brendan M., Tello-Aburto, Rodolfo, Newar, Tara D., Gerwick, William H., Murray, Thomas F., Maio, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251536/
https://www.ncbi.nlm.nih.gov/pubmed/25343669
http://dx.doi.org/10.1021/np500644k

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