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The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature

BACKGROUND: Cervical disc arthroplasty (CDA) is a novel motion-preserving procedure that is an alternative to fusion. The Mobi-C disc prosthesis, one of many Food and Drug Administration (FDA)-approved devices for CDA, is the only FDA-approved prosthesis for two-level CDA. Hence, it may allow for im...

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Autores principales: Alvin, Matthew D, Mroz, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251744/
https://www.ncbi.nlm.nih.gov/pubmed/25473319
http://dx.doi.org/10.2147/MDER.S54497
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author Alvin, Matthew D
Mroz, Thomas E
author_facet Alvin, Matthew D
Mroz, Thomas E
author_sort Alvin, Matthew D
collection PubMed
description BACKGROUND: Cervical disc arthroplasty (CDA) is a novel motion-preserving procedure that is an alternative to fusion. The Mobi-C disc prosthesis, one of many Food and Drug Administration (FDA)-approved devices for CDA, is the only FDA-approved prosthesis for two-level CDA. Hence, it may allow for improved outcomes compared with multilevel fusion procedures. PURPOSE: To critically assess the available literature on CDA with the Mobi-C prosthesis, with a focus on two-level CDA. METHODS: All clinical articles involving the Mobi-C disc prosthesis for CDA through September 1, 2014 were identified on Medline. Any paper that presented Mobi-C CDA clinical results was included. Study design, sample size, length of follow-up, use of statistical analysis, quality of life outcome scores, conflict of interest, and complications were recorded. RESULTS: Fifteen studies were included that investigated Mobi-C CDA, only one of which was a level Ib randomized control trial. All studies included showed non-inferiority of one-level Mobi-C CDA to one-level anterior cervical discectomy and fusion (ACDF). Only one study analyzed outcomes of one-level versus two-level Mobi-C CDA, and only one study analyzed two-level Mobi-C CDA versus two-level ACDF. In comparison with other cervical disc prostheses, the Mobi-C prosthesis is associated with higher rates of heterotopic ossification (HO). Studies with conflicts of interest reported lower rates of HO. Adjacent segment degeneration or disease, along with other complications, were not assessed in most studies. CONCLUSION: One-level Mobi-C CDA is non-inferior, but not superior, to one-level ACDF for patients with cervical degenerative disc disease. The Mobi-C CDA procedure is associated with high rates of HO. Two-level Mobi-C CDA may be superior to two-level ACDF. However, insufficient evidence exists, thereby mandating a need for unbiased, well-designed prospective studies with well-defined outcomes in the future.
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spelling pubmed-42517442014-12-03 The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature Alvin, Matthew D Mroz, Thomas E Med Devices (Auckl) Review BACKGROUND: Cervical disc arthroplasty (CDA) is a novel motion-preserving procedure that is an alternative to fusion. The Mobi-C disc prosthesis, one of many Food and Drug Administration (FDA)-approved devices for CDA, is the only FDA-approved prosthesis for two-level CDA. Hence, it may allow for improved outcomes compared with multilevel fusion procedures. PURPOSE: To critically assess the available literature on CDA with the Mobi-C prosthesis, with a focus on two-level CDA. METHODS: All clinical articles involving the Mobi-C disc prosthesis for CDA through September 1, 2014 were identified on Medline. Any paper that presented Mobi-C CDA clinical results was included. Study design, sample size, length of follow-up, use of statistical analysis, quality of life outcome scores, conflict of interest, and complications were recorded. RESULTS: Fifteen studies were included that investigated Mobi-C CDA, only one of which was a level Ib randomized control trial. All studies included showed non-inferiority of one-level Mobi-C CDA to one-level anterior cervical discectomy and fusion (ACDF). Only one study analyzed outcomes of one-level versus two-level Mobi-C CDA, and only one study analyzed two-level Mobi-C CDA versus two-level ACDF. In comparison with other cervical disc prostheses, the Mobi-C prosthesis is associated with higher rates of heterotopic ossification (HO). Studies with conflicts of interest reported lower rates of HO. Adjacent segment degeneration or disease, along with other complications, were not assessed in most studies. CONCLUSION: One-level Mobi-C CDA is non-inferior, but not superior, to one-level ACDF for patients with cervical degenerative disc disease. The Mobi-C CDA procedure is associated with high rates of HO. Two-level Mobi-C CDA may be superior to two-level ACDF. However, insufficient evidence exists, thereby mandating a need for unbiased, well-designed prospective studies with well-defined outcomes in the future. Dove Medical Press 2014-11-26 /pmc/articles/PMC4251744/ /pubmed/25473319 http://dx.doi.org/10.2147/MDER.S54497 Text en © 2014 Alvin and Mroz. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Alvin, Matthew D
Mroz, Thomas E
The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title_full The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title_fullStr The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title_full_unstemmed The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title_short The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature
title_sort mobi-c cervical disc for one-level and two-level cervical disc replacement: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251744/
https://www.ncbi.nlm.nih.gov/pubmed/25473319
http://dx.doi.org/10.2147/MDER.S54497
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