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High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10

BACKGROUND: The yeast Pichia pastoris (P. pastoris) has become a popular ‘cell factory’ for producing heterologous proteins, but production widely varies among proteins. Cultivation temperature is frequently reported to significantly affect protein production; however, the underlying mechanisms of t...

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Detalles Bibliográficos
Autores principales:	Zhong, Yongjun, Yang, Lu, Guo, Yugang, Fang, Fang, Wang, Dong, Li, Rui, Jiang, Ming, Kang, Wenyao, Ma, Jiajia, Sun, Jie, Xiao, Weihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251845/ https://www.ncbi.nlm.nih.gov/pubmed/25425395 http://dx.doi.org/10.1186/s12934-014-0163-7

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