The mechanism of H171T resistance reveals the importance of N(δ)-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

BACKGROUND: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an important new class of anti-HIV-1 agents. ALLINIs bind at the IN catalytic core domain (CCD) dimer interface occupying the principal binding pocket of its cellular cofactor LEDGF/p75. Consequently, ALLINIs inhibit HIV-1 IN inter...

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Detalles Bibliográficos
Autores principales: Slaughter, Alison, Jurado, Kellie A, Deng, Nanjie, Feng, Lei, Kessl, Jacques J, Shkriabai, Nikoloz, Larue, Ross C, Fadel, Hind J, Patel, Pratiq A, Jena, Nivedita, Fuchs, James R, Poeschla, Eric, Levy, Ronald M, Engelman, Alan, Kvaratskhelia, Mamuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251946/
https://www.ncbi.nlm.nih.gov/pubmed/25421939
http://dx.doi.org/10.1186/s12977-014-0100-1

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