Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

MUS81-EME1 is a conserved structure-selective endonuclease with a preference for branched DNA substrates in vitro that correspond to intermediates of DNA repair. Cells lacking MUS81 or EME1 show defects in the repair of DNA interstrand crosslinks (ICL) resulting in hypersensitivity to agents such as...

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Detalles Bibliográficos
Autores principales: Nair, Nidhi, Castor, Dennis, Macartney, Thomas, Rouse, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251979/
https://www.ncbi.nlm.nih.gov/pubmed/25224045
http://dx.doi.org/10.1016/j.dnarep.2014.08.004

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