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Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus...

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Autores principales: Alves Dummer, Luana, Pereira Leivas Leite, Fábio, van Drunen Littel-van den Hurk, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252008/
https://www.ncbi.nlm.nih.gov/pubmed/25359626
http://dx.doi.org/10.1186/s13567-014-0111-x
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author Alves Dummer, Luana
Pereira Leivas Leite, Fábio
van Drunen Littel-van den Hurk, Sylvia
author_facet Alves Dummer, Luana
Pereira Leivas Leite, Fábio
van Drunen Littel-van den Hurk, Sylvia
author_sort Alves Dummer, Luana
collection PubMed
description The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. Furthermore, the interactions of gD with the host immune system are discussed. Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration.
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spelling pubmed-42520082014-12-03 Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology Alves Dummer, Luana Pereira Leivas Leite, Fábio van Drunen Littel-van den Hurk, Sylvia Vet Res Review The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. Furthermore, the interactions of gD with the host immune system are discussed. Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration. BioMed Central 2014-10-31 2014 /pmc/articles/PMC4252008/ /pubmed/25359626 http://dx.doi.org/10.1186/s13567-014-0111-x Text en © Alves Dummer et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Alves Dummer, Luana
Pereira Leivas Leite, Fábio
van Drunen Littel-van den Hurk, Sylvia
Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title_full Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title_fullStr Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title_full_unstemmed Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title_short Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology
title_sort bovine herpesvirus glycoprotein d: a review of its structural characteristics and applications in vaccinology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252008/
https://www.ncbi.nlm.nih.gov/pubmed/25359626
http://dx.doi.org/10.1186/s13567-014-0111-x
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