Anti-CD45 Radioimmunotherapy with (90)Y but Not (177)Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

Radioimmunotherapy (RIT) for treatment of hematologic malignancies has primarily employed monoclonal antibodies (Ab) labeled with (131)I or (90)Y which have limitations, and alternative radionuclides are needed to facilitate wider adoption of RIT. We therefore compared the relative therapeutic effic...

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Detalles Bibliográficos
Autores principales: Orozco, Johnnie J., Balkin, Ethan R., Gooley, Ted A., Kenoyer, Aimee, Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Hylarides, Mark D., Shadman, Mazyar, Green, Damian J., Gopal, Ajay K., Press, Oliver W., Pagel, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252056/
https://www.ncbi.nlm.nih.gov/pubmed/25460570
http://dx.doi.org/10.1371/journal.pone.0113601

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