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Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy

OBJECTIVE: Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thicknes...

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Autores principales: Worker, Amanda, Blain, Camilla, Jarosz, Jozef, Chaudhuri, K. Ray, Barker, Gareth J., Williams, Steven C. R., Brown, Richard, Leigh, P. Nigel, Simmons, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252086/
https://www.ncbi.nlm.nih.gov/pubmed/25463618
http://dx.doi.org/10.1371/journal.pone.0114167
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author Worker, Amanda
Blain, Camilla
Jarosz, Jozef
Chaudhuri, K. Ray
Barker, Gareth J.
Williams, Steven C. R.
Brown, Richard
Leigh, P. Nigel
Simmons, Andrew
author_facet Worker, Amanda
Blain, Camilla
Jarosz, Jozef
Chaudhuri, K. Ray
Barker, Gareth J.
Williams, Steven C. R.
Brown, Richard
Leigh, P. Nigel
Simmons, Andrew
author_sort Worker, Amanda
collection PubMed
description OBJECTIVE: Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thickness, surface area and grey matter volume to identify unique morphological patterns of cortical atrophy in PD, MSA and PSP and to relate these patterns of change to disease duration and clinical features. METHODS: High resolution 3D T1-weighted MRI volumes were acquired from 14 PD patients, 18 MSA, 14 PSP and 19 healthy control participants. Cortical thickness, surface area and volume analyses were carried out using the automated surface-based analysis package FreeSurfer (version 5.1.0). Measures of disease severity and duration were assessed for correlation with cortical morphometric changes in each clinical group. RESULTS: Results show that in PSP, widespread cortical thinning and volume loss occurs within the frontal lobe, particularly the superior frontal gyrus. In addition, PSP patients also displayed increased surface area in the pericalcarine. In comparison, PD and MSA did not display significant changes in cortical morphology. CONCLUSION: These results demonstrate that patients with clinically established PSP exhibit distinct patterns of cortical atrophy, particularly affecting the frontal lobe. These results could be used in the future to develop a useful clinical application of MRI to distinguish PSP patients from PD and MSA patients.
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spelling pubmed-42520862014-12-05 Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy Worker, Amanda Blain, Camilla Jarosz, Jozef Chaudhuri, K. Ray Barker, Gareth J. Williams, Steven C. R. Brown, Richard Leigh, P. Nigel Simmons, Andrew PLoS One Research Article OBJECTIVE: Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thickness, surface area and grey matter volume to identify unique morphological patterns of cortical atrophy in PD, MSA and PSP and to relate these patterns of change to disease duration and clinical features. METHODS: High resolution 3D T1-weighted MRI volumes were acquired from 14 PD patients, 18 MSA, 14 PSP and 19 healthy control participants. Cortical thickness, surface area and volume analyses were carried out using the automated surface-based analysis package FreeSurfer (version 5.1.0). Measures of disease severity and duration were assessed for correlation with cortical morphometric changes in each clinical group. RESULTS: Results show that in PSP, widespread cortical thinning and volume loss occurs within the frontal lobe, particularly the superior frontal gyrus. In addition, PSP patients also displayed increased surface area in the pericalcarine. In comparison, PD and MSA did not display significant changes in cortical morphology. CONCLUSION: These results demonstrate that patients with clinically established PSP exhibit distinct patterns of cortical atrophy, particularly affecting the frontal lobe. These results could be used in the future to develop a useful clinical application of MRI to distinguish PSP patients from PD and MSA patients. Public Library of Science 2014-12-02 /pmc/articles/PMC4252086/ /pubmed/25463618 http://dx.doi.org/10.1371/journal.pone.0114167 Text en © 2014 Worker et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Worker, Amanda
Blain, Camilla
Jarosz, Jozef
Chaudhuri, K. Ray
Barker, Gareth J.
Williams, Steven C. R.
Brown, Richard
Leigh, P. Nigel
Simmons, Andrew
Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title_full Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title_fullStr Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title_full_unstemmed Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title_short Cortical Thickness, Surface Area and Volume Measures in Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy
title_sort cortical thickness, surface area and volume measures in parkinson's disease, multiple system atrophy and progressive supranuclear palsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252086/
https://www.ncbi.nlm.nih.gov/pubmed/25463618
http://dx.doi.org/10.1371/journal.pone.0114167
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