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Osteoblast-Specific Deletion of Pkd2 Leads to Low-Turnover Osteopenia and Reduced Bone Marrow Adiposity

Polycystin-1 (Pkd1) interacts with polycystin-2 (Pkd2) to form an interdependent signaling complex. Selective deletion of Pkd1 in the osteoblast lineage reciprocally regulates osteoblastogenesis and adipogenesis. The role of Pkd2 in skeletal development has not been defined. To this end, we conditio...

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Detalles Bibliográficos
Autores principales:	Xiao, Zhousheng, Cao, Li, Liang, Yingjuan, Huang, Jinsong, Stern, Amber Rath, Dallas, Mark, Johnson, Mark, Quarles, Leigh Darryl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252138/ https://www.ncbi.nlm.nih.gov/pubmed/25464512 http://dx.doi.org/10.1371/journal.pone.0114198

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