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The N-Terminal Fragment of a PB2 Subunit from the Influenza A Virus (A/Hong Kong/156/1997 H5N1) Effectively Inhibits RNP Activity and Viral Replication
BACKGROUND: Influenza A virus has a RNA-dependent RNA polymerase (RdRp) that is composed of three subunits (PB1, PB2 and PA subunit), which assemble with nucleoproteins (NP) and a viral RNA (vRNA) to form a RNP complex in the host nucleus. Recently, we demonstrated that the combination of influenza...
Autores principales: | Kashiwagi, Takahito, Hara, Koyu, Nakazono, Yoko, Uemura, Yusaku, Imamura, Yoshihiro, Hamada, Nobuyuki, Watanabe, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252148/ https://www.ncbi.nlm.nih.gov/pubmed/25460916 http://dx.doi.org/10.1371/journal.pone.0114502 |
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