An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines

BACKGROUND: The Autotransporter pathway, ubiquitous in Gram-negative bacteria, allows the efficient secretion of large passenger proteins via a relatively simple mechanism. Capitalizing on its crystal structure, we have engineered the Escherichia coli autotransporter Hemoglobin protease (Hbp) into a...

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Detalles Bibliográficos
Autores principales: Jong, Wouter SP, Daleke-Schermerhorn, Maria H, Vikström, David, ten Hagen-Jongman, Corinne M, de Punder, Karin, van der Wel, Nicole N, van de Sandt, Carolien E, Rimmelzwaan, Guus F, Follmann, Frank, Agger, Else Marie, Andersen, Peter, de Gier, Jan-Willem, Luirink, Joen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252983/
https://www.ncbi.nlm.nih.gov/pubmed/25421093
http://dx.doi.org/10.1186/s12934-014-0162-8

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