The Functional Characterization of Long Noncoding RNA SPRY4-IT1 in Human Melanoma Cells

Expression of the long noncoding RNA (lncRNA) SPRY4-IT1 is low in normal human melanocytes but high in melanoma cells. siRNA knockdown of SPRY4-IT1 blocks melanoma cell invasion and proliferation, and increases apoptosis. To investigate its function further, we affinity purified SPRY4-IT1 from melan...

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Detalles Bibliográficos
Autores principales: Mazar, Joseph, Zhao, Wei, Khalil, Ahmad M., Lee, Bongyong, Shelley, John, Govindarajan, Subramaniam S., Yamamoto, Fumiko, Ratnam, Maya, Aftab, Muhammad Nauman, Collins, Sheila, Finck, Brian N., Han, Xianlin, Mattick, John S., Dinger, Marcel E., Perera, Ranjan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253410/
https://www.ncbi.nlm.nih.gov/pubmed/25344859

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