Chemosensitization of Solid Tumors by Inhibition of Bcl-xL Expression Using DNAzyme

DNAzymes are a novel class of gene suppressors that selectively bind to an RNA substrate by Watson-Crick base pairing and cleave phosphodiester bonds. To explore the potential for therapeutic use of catalytic DNA molecules, active DNAzymes targeting the bcl-xL gene were generated through a multiplex...

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Detalles Bibliográficos
Autores principales: Yu, Xiaohui, Yang, Lifang, Cairns, Murray J., Dass, Crispin, Saravolac, Edward, Li, Xiong, Sun, Lun-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253417/
https://www.ncbi.nlm.nih.gov/pubmed/25344863

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