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Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms
Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance to IM and second generation tyrosine kinase inhibitors (TKI). Therefore it is urgent to search for n...
Autores principales: | Chen, Xin, Shi, Xianping, Zhao, Chong, Li, Xiaofen, Lan, Xiaoying, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Liao, Siyan, Zang, Dan, Song, Wenbin, Liu, Quentin, Carter, Bing Z., Dou, Q. Ping, Wang, Xuejun, Liu, Jinbao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253423/ https://www.ncbi.nlm.nih.gov/pubmed/25193854 |
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