Na(+) current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression

Mouse pancreatic β- and α-cells are equipped with voltage-gated Na(+) currents that inactivate over widely different membrane potentials (half-maximal inactivation (V(0.5)) at −100 mV and −50 mV in β- and α-cells, respectively). Single-cell PCR analyses show that both α- and β-cells have Na(v)1.3 (S...

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Detalles Bibliográficos
Autores principales: Zhang, Quan, Chibalina, Margarita V, Bengtsson, Martin, Groschner, Lukas N, Ramracheya, Reshma, Rorsman, Nils J G, Leiss, Veronika, Nassar, Mohammed A, Welling, Andrea, Gribble, Fiona M, Reimann, Frank, Hofmann, Franz, Wood, John N, Ashcroft, Frances M, Rorsman, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Molecular and Cellular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253470/
https://www.ncbi.nlm.nih.gov/pubmed/25172946
http://dx.doi.org/10.1113/jphysiol.2014.274209

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