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Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.

BACKGROUND: Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. However, diagnosis of intraventricular dyssynchrony in patients with AF is difficult due to beat-to-beat variation. Additionally, evaluation of mechanical dyssynchrony in the traditional method is base...

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Autores principales: Sadeghpour, Anita, Hoghooghi, Alireza, Alizadehsani, Zahra, Rezaei, Mohsen, Aghapour, Sevil, Haghjoo, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253764/
https://www.ncbi.nlm.nih.gov/pubmed/25478499
http://dx.doi.org/10.5812/cardiovascmed.8776
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author Sadeghpour, Anita
Hoghooghi, Alireza
Alizadehsani, Zahra
Rezaei, Mohsen
Aghapour, Sevil
Haghjoo, Majid
author_facet Sadeghpour, Anita
Hoghooghi, Alireza
Alizadehsani, Zahra
Rezaei, Mohsen
Aghapour, Sevil
Haghjoo, Majid
author_sort Sadeghpour, Anita
collection PubMed
description BACKGROUND: Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. However, diagnosis of intraventricular dyssynchrony in patients with AF is difficult due to beat-to-beat variation. Additionally, evaluation of mechanical dyssynchrony in the traditional method is based on average of 5 to 10 beats, which is exhausting and time consuming. Single-beat evaluation of a beat with equal subsequent cardiac cycles has been proposed as an accurate method in patients with AF. OBJECTIVES: We proposed to evaluate intraventricular mechanical dyssynchrony by measuring time-to-peak systolic velocity between basolateral and basoseptal segments (septum to lateral wall delay) using Tissue Doppler Study (TDI) by two different methods. MATERIALS AND METHODS: 31 patient (68 ± 10.3 years) with heart failure (EF < 35%) and AF rhythm, R-R cycle length more than 500 msec were evaluated. We found a target beat in which preceding R-R (R-R1) to pre-preceding R-R (R-R2) ratio was 1(RR1/RR2 = 1) then measured the intraventricular dyssynchrony in that cycle. Intraventricular dyssynchrony was also determined and averaged for 8 consecutive cardiac cycles. The values at RR1/RR2 = 1 were compared with the average of intraventricular dyssynchrony in eight cycles and the relationship between dyssynchrony were evaluated by paired T-test, linear Pearson correlation (r2), linear regression analysis. RESULTS: The average of dyssynchrony in eight cycles showed a positive correlation with dyssynchrony in target beat RR1/RR2 = 1. Average of dyssynchrony in target beat was 46.77 msec, and average of 8 cycle was = 47.701, (P value = 0.776, Pearson linear correlation 0.769). CONCLUSIONS: Measurement of intraventricular dyssynchromy in basoseptal and basolateral segments in AF and heart failure patients in a single beat with RR1/RR2 = 1 , were very similar to the average value of eight cardiac cycle.
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spelling pubmed-42537642014-12-04 Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction. Sadeghpour, Anita Hoghooghi, Alireza Alizadehsani, Zahra Rezaei, Mohsen Aghapour, Sevil Haghjoo, Majid Res Cardiovasc Med Research Article BACKGROUND: Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. However, diagnosis of intraventricular dyssynchrony in patients with AF is difficult due to beat-to-beat variation. Additionally, evaluation of mechanical dyssynchrony in the traditional method is based on average of 5 to 10 beats, which is exhausting and time consuming. Single-beat evaluation of a beat with equal subsequent cardiac cycles has been proposed as an accurate method in patients with AF. OBJECTIVES: We proposed to evaluate intraventricular mechanical dyssynchrony by measuring time-to-peak systolic velocity between basolateral and basoseptal segments (septum to lateral wall delay) using Tissue Doppler Study (TDI) by two different methods. MATERIALS AND METHODS: 31 patient (68 ± 10.3 years) with heart failure (EF < 35%) and AF rhythm, R-R cycle length more than 500 msec were evaluated. We found a target beat in which preceding R-R (R-R1) to pre-preceding R-R (R-R2) ratio was 1(RR1/RR2 = 1) then measured the intraventricular dyssynchrony in that cycle. Intraventricular dyssynchrony was also determined and averaged for 8 consecutive cardiac cycles. The values at RR1/RR2 = 1 were compared with the average of intraventricular dyssynchrony in eight cycles and the relationship between dyssynchrony were evaluated by paired T-test, linear Pearson correlation (r2), linear regression analysis. RESULTS: The average of dyssynchrony in eight cycles showed a positive correlation with dyssynchrony in target beat RR1/RR2 = 1. Average of dyssynchrony in target beat was 46.77 msec, and average of 8 cycle was = 47.701, (P value = 0.776, Pearson linear correlation 0.769). CONCLUSIONS: Measurement of intraventricular dyssynchromy in basoseptal and basolateral segments in AF and heart failure patients in a single beat with RR1/RR2 = 1 , were very similar to the average value of eight cardiac cycle. Kowsar 2013-05-20 2013-05 /pmc/articles/PMC4253764/ /pubmed/25478499 http://dx.doi.org/10.5812/cardiovascmed.8776 Text en Copyright © 2013, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sadeghpour, Anita
Hoghooghi, Alireza
Alizadehsani, Zahra
Rezaei, Mohsen
Aghapour, Sevil
Haghjoo, Majid
Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title_full Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title_fullStr Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title_full_unstemmed Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title_short Single Beat Determination of Intraventricular Systolic Dyssynchrony in Patients with Atrial Fibrillation and Systolic Dysfunction.
title_sort single beat determination of intraventricular systolic dyssynchrony in patients with atrial fibrillation and systolic dysfunction.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253764/
https://www.ncbi.nlm.nih.gov/pubmed/25478499
http://dx.doi.org/10.5812/cardiovascmed.8776
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