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Discovery of β-lactam-resistant variants in diverse pneumococcal populations
Understanding of antibiotic resistance in Streptococcus pneumoniae has been hindered by the low frequency of recombination events in bacteria and thus the presence of large linked haplotype blocks, which preclude identification of causative variants. A recent study combining a large number of genome...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254413/ https://www.ncbi.nlm.nih.gov/pubmed/25473434 http://dx.doi.org/10.1186/s13073-014-0072-8 |
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| author | Hakenbeck, Regine |
| author_facet | Hakenbeck, Regine |
| author_sort | Hakenbeck, Regine |
| collection | PubMed |
| description | Understanding of antibiotic resistance in Streptococcus pneumoniae has been hindered by the low frequency of recombination events in bacteria and thus the presence of large linked haplotype blocks, which preclude identification of causative variants. A recent study combining a large number of genomes of resistant phenotypes has given an insight into the evolving resistance to β-lactams, providing the first large-scale identification of candidate variants underlying resistance. |
| format | Online Article Text |
| id | pubmed-4254413 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42544132014-12-04 Discovery of β-lactam-resistant variants in diverse pneumococcal populations Hakenbeck, Regine Genome Med Research Highlight Understanding of antibiotic resistance in Streptococcus pneumoniae has been hindered by the low frequency of recombination events in bacteria and thus the presence of large linked haplotype blocks, which preclude identification of causative variants. A recent study combining a large number of genomes of resistant phenotypes has given an insight into the evolving resistance to β-lactams, providing the first large-scale identification of candidate variants underlying resistance. BioMed Central 2014-09-25 /pmc/articles/PMC4254413/ /pubmed/25473434 http://dx.doi.org/10.1186/s13073-014-0072-8 Text en © Hakenbeck; licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Research Highlight Hakenbeck, Regine Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title | Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title_full | Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title_fullStr | Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title_full_unstemmed | Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title_short | Discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| title_sort | discovery of β-lactam-resistant variants in diverse pneumococcal populations |
| topic | Research Highlight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254413/ https://www.ncbi.nlm.nih.gov/pubmed/25473434 http://dx.doi.org/10.1186/s13073-014-0072-8 |
| work_keys_str_mv | AT hakenbeckregine discoveryofblactamresistantvariantsindiversepneumococcalpopulations |